7-(6-Methoxycarbonyl-6-methyl-heptylsulfanyl)-2,2-dimethyl-heptan oic acid methyl ester | 412935-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-(6-Methoxycarbonyl-6-methyl-heptylsulfanyl)-2,2-dimethyl-heptan oic acid methyl ester
• 英文别名: Methyl 7-(7-methoxy-6,6-dimethyl-7-oxoheptyl)sulfanyl-2,2-dimethylheptanoate
• CAS: 412935-04-7
• 化学式: C₂₀H₃₈O₄S
• 分子量: 374.585
• InChiKey: OIBNSZZAVKTQOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Sulfide and disulfide compounds and compositions for cholesterol management and related uses
  申请人：Dasseux Henri Jean-Louis

  公开号：US20050020694A1

  公开（公告）日：2005-01-27

  The invention encompasses novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涵盖了新型硫化物和二硫化物化合物，包含硫化物和二硫化物化合物的组合物，以及使用含有醚化合物的组合物进行治疗和预防心血管疾病、脂质代谢异常、蛋白质异常和葡萄糖代谢紊乱的方法。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，本发明的化合物、组合物和方法与其他治疗剂如降胆固醇和降血糖药物联合治疗非常有效。
• US6703422B2
  申请人：——

  公开号：US6703422B2

  公开（公告）日：2004-03-09