8-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-6-(2-chlorophenyl)-1-(2,6-difluorophenyl)-2H-quinolizin-2-one | 927175-70-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 8-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-6-(2-chlorophenyl)-1-(2,6-difluorophenyl)-2H-quinolizin-2-one
• 英文别名: 8-(1-tert-butyl-3,6-dihydro-2H-pyridin-4-yl)-6-(2-chlorophenyl)-1-(2,6-difluorophenyl)quinolizin-2-one
• CAS: 927175-70-0
• 化学式: C₃₀H₂₇ClF₂N₂O
• 分子量: 505.007
• InChiKey: JVKRSWOUYWZHQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• P38 KINASE INHIBITING AGENTS
  申请人：Chen Meng-Hsin

  公开号：US20110183959A1

  公开（公告）日：2011-07-28

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式（I）所描述的化合物或其药学上可接受的盐：是p38抑制剂，并可用于治疗炎症，例如治疗类风湿性关节炎、类风湿性脊柱炎、骨关节炎、痛风性关节炎和其他关节炎症状；炎症性关节、湿疹、牛皮癣或其他炎症性皮肤病，如晒伤；炎症性眼部疾病，包括结膜炎；发热、疼痛和其他与炎症相关的疾病。
• P38 Kinase Inhibiting Agents
  申请人：Chen Meng-Hsin

  公开号：US20090131472A1

  公开（公告）日：2009-05-21

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式（I）所描述的化合物或其药学上可接受的盐：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊柱炎，骨关节炎，痛风性关节炎和其他关节炎症状；发炎的关节，湿疹，牛皮癣或其他炎症性皮肤病，如晒伤；炎症性眼部疾病，包括结膜炎；与炎症相关的发热，疼痛和其他疾病。
• HETEROBICYCLIC COMPOUNDS USEFUL AS P38 KINASE INHIBITING AGENTS
  申请人：Merck and Co., Inc.

  公开号：EP1915373A1

  公开（公告）日：2008-04-30
• US7879875B2
  申请人：——

  公开号：US7879875B2

  公开（公告）日：2011-02-01
• [EN] HETEROBICYCLIC COMPOUNDS USEFUL AS P38 KINASE INHIBITING AGENTS<br/>[FR] COMPOSÉS HÉTÉROBICYCLIQUES UTILES EN TANT QU'AGENTS INHIBITEURS DE KINASE P38
  申请人：MERCK & CO INC

  公开号：WO2007021710A1

  公开（公告）日：2007-02-22

  [EN] Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
  [FR] La présente invention se rapporte aux composés décrits par la formule chimique (I) ou aux sels pharmaceutiquement acceptables de celle-ci : (I) sont les inhibiteurs de p38 et sont utiles dans le traitement de l'inflammation comme dans le traitement de la polyarthrite rhumatoïde, la spondylarthrite ankylosante, l'arthrite goutteuse et les autres pathologies cliniques arthritiques ; les inflammations articulaires, l'eczéma, le psoriasis ou d'autres pathologies cliniques inflammatoires de la peau tels que l'érythème solaire ; les pathologies cliniques inflammatoires des yeux notamment la conjonctivite ; le pyrésis, la douleur et autres pathologies cliniques associées à l'inflammation.