3-isobutyl-6-isobutylidene-1,4-dimethyl-piperazine-2,5-dione | 70359-80-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-isobutyl-6-isobutylidene-1,4-dimethyl-piperazine-2,5-dione
• 英文别名: (6E)-1,4-dimethyl-3-(2-methylpropyl)-6-(2-methylpropylidene)piperazine-2,5-dione
• CAS: 70359-80-7
• 化学式: C₁₄H₂₄N₂O₂
• 分子量: 252.357
• InChiKey: PLNGTWWDIQCXJS-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Small Molecule Inhibitors of N-Terminus Activation of the Androgen Receptor
  申请人：Sadar Marianne D.

  公开号：US20110230539A1

  公开（公告）日：2011-09-22

  Compounds having a structure of Formula (A) are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are provided. Uses of compounds having a structure of Formula (F) for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

  提供具有公式（A）结构的化合物。提供使用这种化合物治疗各种疾病的方法，包括前列腺癌以及涉及这种化合物的治疗方法。还提供具有公式（F）结构的化合物用于治疗各种疾病的方法，包括前列腺癌以及涉及这种化合物的治疗方法。
• SMALL MOLECULE INHIBITORS OF N-TERMINUS ACTIVATION OF THE ANDROGEN RECEPTOR
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20170239216A1

  公开（公告）日：2017-08-24

  Compounds having a structure of Formula (A) are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are provided. Uses of compounds having a structure of Formula (F) for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
• US9487479B2
  申请人：——

  公开号：US9487479B2

  公开（公告）日：2016-11-08