2-Methyl-3-hydroxy-penten-2-saeureethylester | 78524-84-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Methyl-3-hydroxy-penten-2-saeureethylester
• 英文别名: seqcis-α.γ-Dimethyl-acetessigsaeureethylester-enol；3-hydroxy-2-methyl-pent-2-enoic acid ethyl ester；3-Hydroxy-2-methyl-pent-2-ensaeure-aethylester；ethyl (Z)-3-hydroxy-2-methylpent-2-enoate
• CAS: 78524-84-2
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: OHIBRIVEZXGPQZ-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Taste masked pharmaceutical composition comprising pH sensitive polymer
  申请人：Kulkarni Gopalkrishna Mohan

  公开号：US20050136115A1

  公开（公告）日：2005-06-23

  The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The compositions used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.

  本发明公开了一种基本无定形的药物组合物，该组合物包含一种可以以多种多晶体形式存在的药物和一种对 pH 值敏感的聚合物，后者可以在配制和复溶过程中抑制药物结晶。分子量较高的聚合物在较低的负载量下更有效，特别是当药物聚合物基质是通过溶剂蒸发或溶剂萃取技术制备时。作为干糖浆使用的组合物可以保持药物的生物利用度，并在组合物重组时有效掩盖药物的味道。
• TASTE MASKED PHARMACEUTICAL COMPOSITION COMPRISING PH SENSITIVE POLYMER
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：EP1694303A1

  公开（公告）日：2006-08-30
• TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：EP1694302A1

  公开（公告）日：2006-08-30
• Taste masked pharmaceutical compositions comprising bitter drug and pH sensitive polymer
  申请人：Kulkarni G. Mohan

  公开号：US20050136114A1

  公开（公告）日：2005-06-23

  The present invention discloses pharmaceutical compositions comprising of pH sensitive polymers used for taste masking highly bitter drugs. The pH sensitive polymer acts as a reverse enteric coating, which is soluble in the acidic pH range 1.0 to 3.0 normally found in the stomach but is insoluble in the pH range 3.5 to 7 thus inhibiting the release of the bitter drug at the pH of saliva and also at the pH of reconstitution medium in case of liquid orals.
• US7282218B2
  申请人：——

  公开号：US7282218B2

  公开（公告）日：2007-10-16