2-tert.-Butyl-3-carbomethoxypropionsaeure | 59719-23-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-tert.-Butyl-3-carbomethoxypropionsaeure
• 英文别名: 2-(2-Methoxy-2-oxoethyl)-3,3-dimethylbutanoic acid
• CAS: 59719-23-2
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: FALXSZSJDKOVRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BENZIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING BENZIDINE DERIVATIVE FOR TREATING LIVER DISEASE CAUSED BY HEPATITIS C VIRUS
  申请人：SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

  公开号：US20160031810A1

  公开（公告）日：2016-02-04

  The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.

  揭示的化合物对C型病毒具有抗病毒活性，包括其光学异构体、药学上可接受的盐、制备方法以及含有其作为活性成分的药物组合物，用于预防或治疗由丙型肝炎病毒引起的肝病。根据本发明的苯胺衍生物对丙型肝炎病毒具有出色的抗病毒活性，在活体内表现出优秀的药用活性，因此含有其作为活性成分的药物组合物可作为用于预防或治疗由C型病毒引起的肝病，如急性丙型肝炎、慢性丙型肝炎、肝硬化或肝细胞癌等的药物组合物。
• US9598362B2
  申请人：——

  公开号：US9598362B2

  公开（公告）日：2017-03-21
• [EN] ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS<br/>[FR] AMÉLIORATION DE LA POLYMÉRISATION D'ACIDES NUCLÉIQUES PAR DES COMPOSÉS AROMATIQUES
  申请人：STRATOS GENOMICS INC

  公开号：WO2020263703A1

  公开（公告）日：2020-12-30

  The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.