3-Hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-dione | 1357289-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-Hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-dione
• CAS: 1357289-11-2
• 化学式: C₈H₇NO₄
• 分子量: 181.148
• InChiKey: LLYJXZVCJVOYJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-dione 在 N-溴代丁二酰亚胺(NBS) 、 溶剂黄146 作用下， 以 异丙醇 、 乙腈 为溶剂， 反应 39.83h， 生成 (7R)-13-bromo-7-methyl-11-phenylmethoxy-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-9,12-dione
  参考文献：
  名称：

  PROCESS FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP2602260B1
• 作为产物：
  描述：

  靠曼酸 、 氨基乙醛缩二甲醇 以 水 为溶剂， 反应 5.0h， 以76%的产率得到3-Hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-dione
  参考文献：
  名称：

  PROCESS FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP2602260B1

文献信息

• Crystalline dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
  申请人：Shionogi & Co., Ltd.

  公开号：US10000508B2

  公开（公告）日：2018-06-19

  A crystalline dimethyl 2-(benzyloxy)-1-(2,2-diethoxy-ethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate of the formula (U1):

  式 (U1) 的 2-(苄氧基)-1-(2,2-二乙氧基-乙基)-4-氧代-1,4-二氢吡啶-2,5-二甲酸二甲酯结晶：
• Process for Preparing Compound Having HIV Integrase Inhibitory Activity
  申请人：Sumino Yukihito

  公开号：US20140011995A1

  公开（公告）日：2014-01-09

  A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].
• Method of producing compounds having HIV integrase inhivitory activity
  申请人：Shionogi & Co., Ltd.

  公开号：US20150038702A1

  公开（公告）日：2015-02-05

  A process for preparing a compound represented by formula (Y1) or (Y2) wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) wherein R 1d , R 2d , and R 4d are as defined herein.
• METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170240564A1

  公开（公告）日：2017-08-24

  A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].
• US9321789B2
  申请人：——

  公开号：US9321789B2

  公开（公告）日：2016-04-26