2-(2-isobutylthiazol-5-yl)-4-trifluoromethylphenylamine | 1397709-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-isobutylthiazol-5-yl)-4-trifluoromethylphenylamine
• 英文别名: 2-[2-(2-Methylpropyl)-1,3-thiazol-5-yl]-4-(trifluoromethyl)aniline；2-[2-(2-methylpropyl)-1,3-thiazol-5-yl]-4-(trifluoromethyl)aniline
• CAS: 1397709-74-8
• 化学式: C₁₄H₁₅F₃N₂S
• 分子量: 300.348
• InChiKey: IHFLRVIBZQDARL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-异丁基噻唑 、 4-氨基-3-碘三氟甲苯 在 potassium acetate 、 palladium diacetate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 20.0h， 以83%的产率得到2-(2-isobutylthiazol-5-yl)-4-trifluoromethylphenylamine
  参考文献：
  名称：

  Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction

  摘要：

  The palladium-catalysed direct arylation of heteroaromatics with unprotected iodoanilines proceeds in moderate to high yields using only 1 mol% Pd(OAc)(2) as the catalyst and potassium acetate as the base. No amination reaction was observed under these conditions. A wide variety of heteroarenes have been successfully employed.

  DOI：

  10.1055/s-0031-1291124

文献信息

• Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction
  作者：Hamed Ammar、Henri Doucet、Anissa Beladhria、Kassem Beydoun、Ridha Salem

  DOI：10.1055/s-0031-1291124

  日期：2012.7

  The palladium-catalysed direct arylation of heteroaromatics with unprotected iodoanilines proceeds in moderate to high yields using only 1 mol% Pd(OAc)(2) as the catalyst and potassium acetate as the base. No amination reaction was observed under these conditions. A wide variety of heteroarenes have been successfully employed.