S-[13N]nitrosothiophenol | 1232679-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-[13N]nitrosothiophenol
• CAS: 1232679-93-4
• 化学式: C₆H₅NOS
• 分子量: 138.171
• InChiKey: UDZFSIQDXJENME-JZRMKITLSA-N

反应信息

• 作为产物：
  描述：

  苯硫酚 在 [13N]NO2(1-) 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 反应 0.02h， 生成 S-[13N]nitrosothiophenol
  参考文献：
  名称：

  Fully automated synthesis of 13N-labeled nitrosothiols

  摘要：

  In the present Letter, a fast, automated, and reproducible method for the synthesis of S-[N-13]nitrosothiols is reported. The labeling strategy is based on trapping [N-13]NO2- in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.122