didodecyl L-aspartate | 114119-18-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: didodecyl L-aspartate
• 英文别名: Didodecyl 2-aminobutanedioate
• CAS: 114119-18-5
• 化学式: C₂₈H₅₅NO₄
• 分子量: 469.749
• InChiKey: OWELWTUHYRGKKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  33
• 可旋转键数：
  27
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  p-hydroxypropyl-p'-carboxyazobenzene 、 didodecyl L-aspartate 在 氰基磷酸二乙酯 、 三氯氧磷 作用下， 生成 2-{4-[4-(3-Phosphonooxy-propoxy)-phenylazo]-benzoylamino}-succinic acid didodecyl ester
  参考文献：
  名称：

  Kim, Jong-Mok; Kunitake, Toyoki, Chemistry Letters, 1989, p. 959 - 962

  摘要：

  DOI：

文献信息

• Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
  申请人：ADOCIA

  公开号：US20170348396A1

  公开（公告）日：2017-12-07

  A physically stable compositions in the form of an injectable aqueous solution, the pH of which is from 6.0 to 8.0: a basal insulin of which the isoelectric point (pI) is from 5.8 to 8.5, a prandial insulin or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical.

  一种物理稳定的组合物，以可注射的水溶液的形式存在，其pH值为6.0至8.0：其中的一种基础胰岛素的等电点（pI）为5.8至8.5，一种餐后胰岛素或肠道激素，以及一种带有羧酸基团和至少一个疏水基团的共聚氨基酸。
• Anionic polysaccharides functionalized by at least two hydrophobic groups carried by an at least trivalent spacer
  申请人：CHARVET Richard

  公开号：US20110195913A1

  公开（公告）日：2011-08-11

  Anionic polysaccharide derivatives partially functionalized by at least two vicinal hydrophobic groups, the hydrophobic groups, which are identical or different, being carried by an at least trivalent radical or spacer, a method of synthesis of the functionalized polysaccharides, and pharmaceutical compositions having one of the polysaccharides and at least one active principle are provided.

  本发明提供了部分功能化的阴离子多糖衍生物，其至少由两个相邻的疏水基团部分功能化，这些疏水基团相同或不同，由至少三价基团或空间支架携带，提供了功能化多糖的合成方法以及含有其中一种多糖和至少一种活性成分的制药组合物。
• Polyphenylene sulfide resin composition
  申请人：GE PLASTICS JAPAN LIMITED

  公开号：EP0368413A2

  公开（公告）日：1990-05-16

  A resin composition comprising polyphenylene sulfide and polyphenylene ether is modified with the addition of a compound having a functional group or by modifying the polyphenylene ether, whereby impact resistance of a molded article produced from the resin composition is improved.

  通过添加具有官能团的化合物或改性聚苯醚，对由聚苯硫醚和聚苯醚组成的树脂组合物进行改性，从而提高用该树脂组合物生产的模塑件的抗冲击性。
• Injectable solution at pH 7 comprising at least one basal insulin the pi of which is between 5.8 and 8.5 and a substituted co-polyamino acid
  申请人：ADOCIA

  公开号：US10335489B2

  公开（公告）日：2019-07-02

  A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, including at least (a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and (b) a co-polyamino acid bearing carboxylate charges and substituted with hydrophobic radicals. In one embodiment, the compositions also include a prandial insulin and/or a gut hormone.

  一种可注射水溶液形式的组合物，其 pH 值介于 6.0 和 8.0 之间，至少包括(a) 基础胰岛素，其等电点 pI 介于 5.8 和 8.5 之间；以及(b) 带有羧酸电荷并被疏水基取代的共聚氨基酸。在一个实施方案中，组合物还包括胰岛素和/或肠道激素。
• Injectable solution at pH 7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
  申请人：ADOCIA

  公开号：US10383920B2

  公开（公告）日：2019-08-20

  A physically stable compositions in the form of an injectable aqueous solution, the pH of which is from 6.0 to 8.0, including at least: a basal insulin of which the isoelectric point (pI) is from 5.8 to 8.5, and a co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical.

  一种可注射水溶液形式的物理稳定组合物，其 pH 值为 6.0 至 8.0，至少包括：等电点（pI）为 5.8 至 8.5 的基础胰岛素，以及带有羧酸电荷和至少一个疏水基的共聚氨基酸。