Fam-RRC(gg)-NH | 1208381-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Fam-RRC(gg)-NH
• CAS: 1208381-97-8
• 化学式: C₅₆H₇₄N₁₀O₉S
• 分子量: 1063.33
• InChiKey: UHVHESLFTVEDQV-DICSPRISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.62
• 重原子数：
  76.0
• 可旋转键数：
  28.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  330.18
• 氢给体数：
  12.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  (2E,6E,10E)-1-溴-3,7,11,15-四甲基-2,6,10,14-十六碳四烯 、 在 zinc diacetate 、 三氟乙酸 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 Fam-RRC(gg)-NH
  参考文献：
  名称：

  Investigation of the sequence and length dependence for cell-penetrating prenylated peptides

  摘要：

  Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this study a series of such peptides was synthesized to examine the relationship between peptide sequence and level of peptide internalization and to probe their mechanism of internalization. This study revealed that prenylated peptides internalize via a non-endocytotic pathway regardless of sequence. Sequence length and identity was found to play a role in peptide uptake but prenylated sequences as short as two amino acids were found to exhibit significant cell penetrating properties. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.026