6-(4-fluoro-2-methoxyphenyl)-5-(2-methoxy-5-methylphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline | 929527-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6-(4-fluoro-2-methoxyphenyl)-5-(2-methoxy-5-methylphenylaminomethyl)-2,2,4-trimethyl-1,2-dihydroquinoline
• 英文别名: N-[[6-(4-fluoro-2-methoxyphenyl)-2,2,4-trimethyl-1H-quinolin-5-yl]methyl]-2-methoxy-5-methylaniline
• CAS: 929527-06-0
• 化学式: C₂₈H₃₁FN₂O₂
• 分子量: 446.565
• InChiKey: HCVMWHMYXUNDBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity
  申请人：Matsuda Mamoru

  公开号：US20090326009A1

  公开（公告）日：2009-12-31

  An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R 2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R 3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R 4 and R 5 represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R 7 represents OR 8 , NR 8 R 9 , SR 8 , S(O)R 8 or S(O) 2 R 8 , wherein R 8 represents an aryl group, a heterocyclic group or the like and R 9 represents a hydrogen atom or the like.

  本发明的目的是研究合成一种新型1,2-二氢喹啉衍生物，并发现该衍生物的药理作用。通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面具有有效性。在该式中，环X表示苯环或吡啶环；R1表示卤素原子、烷基、羟基、烷氧基、氨基或类似物；p表示0至5的整数；R2表示卤素原子、烷基、羟基或类似物；q表示0至2的整数；R3表示氢原子、烷基、烯基或类似物；R4和R5表示氢原子或类似物；R6表示氢原子或类似物；A表示烷基链或类似物；R7表示OR8、NR8R9、SR8、S（O）R8或S（O）2R8，其中R8表示芳基、杂环基或类似物，R9表示氢原子或类似物。
• Method for preventing or treating a glucocorticoid receptor-related disease
  申请人：Matsuda Mamoru

  公开号：US20110263589A1

  公开（公告）日：2011-10-27

  A method of preventing or treating a glucocorticoid receptor-related disease involving administering a therapeutically effective amount of a 1,2-dihydroquinoline compound or a pharmaceutically acceptable salt thereof.

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，包括给予治疗有效量的1,2-二氢喹啉化合物或其药学上可接受的盐。
• NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1944290B1

  公开（公告）日：2013-12-04
• US8017775B2
  申请人：——

  公开号：US8017775B2

  公开（公告）日：2011-09-13
• US8420635B2
  申请人：——

  公开号：US8420635B2

  公开（公告）日：2013-04-16