[Pd(6-nitro-3-(indolin-2-one)benzothiazoline)2] | 1265075-89-5

• 分子结构分类: 有机化合物
• 英文名称: [Pd(6-nitro-3-(indolin-2-one)benzothiazoline)2]
• CAS: 1265075-89-5
• 化学式: C₂₈H₁₆N₆O₆PdS₂
• 分子量: 703.024
• InChiKey: ARPAXMFUAQGTFI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  6-nitro-3-(indolin-2-one)benzothiazoline 、 palladium dichloride 在 NH₃ 作用下， 以 甲醇 、 水 为溶剂， 生成 [Pd(6-nitro-3-(indolin-2-one)benzothiazoline)2]
  参考文献：
  名称：

  Palladium(II) and platinum(II) derivatives of benzothiazoline ligands: Synthesis, characterization, antimicrobial and antispermatogenic activity

  摘要：

  A series of Pd(II) and Pt(II) complexes with two NS donor ligands, 5-chloro-3-(indolin-2-one)benzothiazoline and 6-nitro-3-(indolin-2-one)benzothiazoline, have been synthesized by the reaction of metal chlorides (PdCl2 and PtCl2) with ligands in 1:2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, H-1 NMR and C-13 NMR spectroscopic techniques for structure elucidation. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown to be more antimicrobial against the microbial species as compared to free ligands. One of the ligands, 5-chloro-3-(indolin-2-one)benzothiazoline and its corresponding palladium and platinum complexes have been tested for their antifertility activity in male albino rats. The marked reduction in sperm motility and density resulted in infertility by 62-90%. Significant alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2010.08.076