N-(2,3-Dimethoxybenzyl)-glycin | 56859-60-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2,3-Dimethoxybenzyl)-glycin
• 英文别名: 2-[(2,3-dimethoxyphenyl)methylazaniumyl]acetate
• CAS: 56859-60-0
• 化学式: C₁₁H₁₅NO₄
• mdl: MFCD11139003
• 分子量: 225.244
• InChiKey: PEYALKSMYNSKRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• US7026282B1
  申请人：——

  公开号：US7026282B1

  公开（公告）日：2006-04-11
• [EN] PEPTIDE ANTAGONISTS OF THE HUMAN UROKINASE RECEPTOR AND METHOD FOR SELECTING THEM<br/>[FR] ANTAGONISTES PEPTIDIQUES DU RECEPTEUR HUMAIN DE L'UROKINASE ET LEUR PROCEDE DE SELECTION
  申请人：CANCERFORSKNINGSFONDEN AF 1989

  公开号：WO2000001802A2

  公开（公告）日：2000-01-13

  A novel set of inhibitors of the binding interaction between human urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR) has been developed. The inhibitors comprise of peptide fragments, monomeric or in multiple copies attached to a common scaffold, in which the amino acid sequence may include uncommon substituted amino acids to partially comprise of peptoid sequences. The present invention also relates to the use of such peptides in therapy, in particular for the treatment of cancer, having developed a modified non-human mammalian receptor to which the novel inhibitors are antagonistic. The invention also relates to a method for selecting peptides antagonizing the binding between uPA and uPAR.