N-Propyl-2-nitro-imidazol | 20358-61-6

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: N-Propyl-2-nitro-imidazol
• 英文别名: 2-nitro-1-propyl-1H-imidazole；2-Nitro-1-propylimidazole
• CAS: 20358-61-6
• 化学式: C₆H₉N₃O₂
• 分子量: 155.156
• InChiKey: PRHDMFJGVCIXAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS
  申请人：MOLTENI Valentina

  公开号：US20140228347A1

  公开（公告）日：2014-08-14

  The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

  本发明提供了化合物及其制药组合物，作为蛋白激酶抑制剂，以及使用这些化合物的方法，用于治疗、改善或预防与异常或失调激酶活性相关的病症。在某些实施例中，本发明提供使用这些化合物的方法，用于治疗、改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα、PDGFRβ）激酶异常激活的疾病或障碍。
• [EN] HYPOXIA ACTIVATED PRODRUGS OF ANTHRACYCLINES<br/>[FR] PROMÉDICAMENTS D'ANTHRACYCLINES ACTIVÉS PAR UNE HYPOXIE
  申请人：THRESHOLD PHARMACEUTICALS INC

  公开号：WO2009018163A1

  公开（公告）日：2009-02-05

  Hypoxia activated prodrug compounds of anthracyclines are useful in the treatment of cancer and other hyperproliferative diseases. Certain compounds contain a 2-nitroimidazole moiety covalently bonded via the 1-N nitrogen atom to an alkylene and/or a heterolalyene linker; the alkylene and/or a heterolalyene linker is covalently bonded to the anthracycline.