(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(imidazo[1,2-b]pyridazin-6-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one | 1236325-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(imidazo[1,2-b]pyridazin-6-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
• 英文别名: (6S)-6-(2-hydroxy-2-methylpropyl)-3-[(1S)-1-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)ethyl]-6-phenyl-1,3-oxazinan-2-one
• CAS: 1236325-01-1
• 化学式: C₂₈H₃₀N₄O₃
• 分子量: 470.571
• InChiKey: MSTDOBPWYBQASR-MMTVBGGISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol-an-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one 、 6-氯咪唑并[1,2-b]哒嗪 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 水 、 碳酸氢钠 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 以65%的产率得到(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(imidazo[1,2-b]pyridazin-6-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
  参考文献：
  名称：

  [EN] DERIVATIVES OF [1, 3] OXAZIN- 2-ONE USEFUL FOR THE TREATMENT OF METABOLIC DISEASES SUCH AS LIPID DISORDERS
  [FR] INHIBITEURS CYCLIQUES DE 11 BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1

  摘要：

  公开号：

  WO2010091067A3

文献信息

• DERIVATIVES OF [1,3]OXAZIN-2-ONE USEFUL FOR THE TREATMENT OF METABOLIC DISEASES SUCH AS LIPID DISORDERS
  申请人：Claremon David A.

  公开号：US20120040973A1

  公开（公告）日：2012-02-16

  This invention relates to novel compounds of an 11 β-HSD1 inhibitor disclosed herein, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11/3-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.

  本发明涉及一种11β-HSD1抑制剂的新化合物、其药学上可接受的盐以及药物组合物，用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病。本发明还涉及这些新化合物的药物组合物和它们在细胞中减少或控制皮质醇的产生或抑制皮质酮转化为皮质醇的方法。
• Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
  申请人：Claremon David

  公开号：US08598163B2

  公开（公告）日：2013-12-03

  This invention relates to novel compounds of an 11 β-HSD1 inhibitor disclosed herein, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11/3-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.

  本发明涉及一种11β-HSD1抑制剂的新化合物，其药学上可接受的盐及其制备的药物组合物，用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病。本发明还涉及这些新化合物的药物组合物和它们用于减少或控制细胞中皮质醇的产生或抑制细胞中皮质酮转化为皮质醇的方法。
• Cyclic inhibitors of 11 ß-hydroxysteroid dehydrogenase 1 useful for the treatment of diseases related to elevated level of cortisol
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：EP2393813B1

  公开（公告）日：2013-07-31
• CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：EP2393813A2

  公开（公告）日：2011-12-14
• US8598163B2
  申请人：——

  公开号：US8598163B2

  公开（公告）日：2013-12-03