1-[Diazo-(4-iodophenyl)methyl]-4-iodobenzene | 60664-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[Diazo-(4-iodophenyl)methyl]-4-iodobenzene
• CAS: 60664-83-7
• 化学式: C₁₃H₈I₂N₂
• 分子量: 446.029
• InChiKey: UMZOFRCRHGXNQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[Diazo-(4-iodophenyl)methyl]-4-iodobenzene 、 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 以 丙酮 为溶剂， 反应 16.0h， 以19%的产率得到(2R,5S,6S,7R)-1-aza-9,9-di(p-iodophenyl)-7-ethoxycarbonyl-8-oxo-3-oxa-2-phenyl-tricyclo[4.1.0^1,5.0^6,7]nonane
  参考文献：
  名称：

  双环内酰胺上未催化的二芳基重氮环丙烷化反应：获得环化脯氨酸的†

  摘要：

  取代的二芳基重氮化合物在衍生自焦谷氨酸的双环不饱和内酰胺上的未催化环加成有效地导致高度官能化的氮杂三环壬烷。该产品易于修饰成脱保护的焦谷氨酸衍生物，可快速获得构象受限的氨基酸及其类似物。对一种革兰氏阳性和一种革兰氏阴性生物的抗菌活性的初步评估表明，在某些情况下，其疗效很高。

  DOI：

  10.1039/c5ob00648a

文献信息

• A novel class of azatricyclononanes: pentasubstituted cyclopropanes from an uncatalysed reaction
  作者：Lawrence Harris、Martin Gilpin、Amber L. Thompson、Andrew R. Cowley、Mark G. Moloney

  DOI：10.1016/j.tetasy.2009.02.037

  日期：2009.5

  The direct and versatile stereoselective synthesis of a novel class of cyclopropyl derivatives of pyroglutamic acid is reported, using substituted diaryldiazo compounds. The course of the reaction has been investigated, and yields of substituted fluorenylcyclopropanes are greater than those of diphenylmethyl-cyclopropane analogues. (C) 2009 Elsevier Ltd. All rights reserved.
• GEMSTONE COATINGS AND METHODS OF MAKING AND USING THE SAME
  申请人：Glisten LLC

  公开号：EP3651606A1

  公开（公告）日：2020-05-20
• MOLECULAR COATINGS AND METHODS OF MAKING AND USING THE SAME
  申请人：Glisten LLC

  公开号：EP3911197A1

  公开（公告）日：2021-11-24
• [EN] GEMSTONE COATINGS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] REVÊTEMENTS DE PIERRES PRÉCIEUSES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
  申请人：GLISTEN LLC

  公开号：WO2019014465A1

  公开（公告）日：2019-01-17

  Disclosed herein are coated gemstones, coatings for gemstones, methods of coating gemstones, and methods of using coatings on gemstones to avoid blemishes on gemstones. In some embodiments, diamonds are functionalized with anchor molecules that bind hydrophilic cyclodextrin molecules to confer hydrophilicity on the diamond. In some embodiments, the diamonds resist dirt and grime build-up.
• [EN] MOLECULAR COATINGS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] REVÊTEMENTS MOLÉCULAIRES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：GLISTEN LLC

  公开号：WO2020150109A1

  公开（公告）日：2020-07-23

  Disclosed herein are molecularly coated surfaces, methods of coating surfaces, and methods of using coatings on surfaces. In some embodiments, the coated surfaces are useful in applications to avoid blemishes on gemstones, confer antimicrobial activity on a surface, confer a therapeutic property to a surface, detect an analyte, change the color of a surface, and or to change the physical and/or chemical properties of a surface.