4-(9H-fluoren-9-yl)butanol | 3952-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-(9H-fluoren-9-yl)butanol
• 英文别名: 4-(9H-fluoren-9-yl)butan-1-ol；9-(4-Hydroxy-butyl)-fluoren；4-(9H-Fluoren-yl)butyl alcohol
• CAS: 3952-37-2
• 化学式: C₁₇H₁₈O
• 分子量: 238.329
• InChiKey: RWFPGIRUXZJSNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(9H-fluoren-9-yl)butanol 在 sodium hydroxide 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.5h， 生成 4-[4-(9H-fluoren-9-yl)butoxy]benzoic acid
  参考文献：
  名称：

  Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes

  摘要：

  A series of fluoren-9-ylalkanoic and alkylbenzoic acids was prepared as simplified analogues of a previously reported series of antiinflammatory agents which act to inhibit neutrophil recruitment into inflamed tissue. The previous compounds (''leumedins'') contained (alkoxycarbonyl)amino or benzoic acid moieties tethered to a fluorene ring. This functionality was replaced with simple structural elements. The new compounds were, in general, found to be more potent than the earlier series at inhibiting adherence of neutrophils to serum-coated wells or endothelial cells in vitro. Compound 9 was approximately 10-fold more potent than the previously reported FMOC-phenylalanine, of which it is an analogue. Similarly, compound 19 was superior in potency to its first generation progenitor, NPC 16570. The new compounds were shown to inhibit neutrophil adherence under conditions in which adherence is mediated by Mac-1 (CD11b/CD18) and LFA-1 (CD11a/CD18); they thus appear to target beta(2)-integrins in their antiadhesion activity. These compounds provide a departure point for the further development of new cell adhesion inhibitors which should exhibit enhanced potency and a more selective mode of action.

  DOI：

  10.1021/jm00010a009
• 作为产物：
  描述：

  2-碘联苯 在 四(三苯基膦)钯 、 sodium formate 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 16.5h， 生成 4-(9H-fluoren-9-yl)butanol
  参考文献：
  名称：

  模块化串联Mizoroki-Heck /还原性Heck反应从环状二芳基碘鎓盐构建芴

  摘要：

  从环状二芳基碘鎓和末端烯烃开始，可以方便地构建各种芴。钯催化的反应会进行一种常规的Mizoroki-Heck反应和一种还原性Heck反应。烯烃的范围很广，导致有29个芴，这将扩大芴储层的结构多样性。

  DOI：

  10.1002/adsc.202001080

文献信息

• The Base-Catalyzed Alkylation of Fluorene and Indene with Alcohols and Diols
  作者：Henry E. Fritz、David W. Peck、Marion A. Eccles、Kenneth E. Atkins

  DOI：10.1021/jo01019a009

  日期：1965.8
• ACTINIC RAY CURABLE COMPOSITION, ACTINIC RAY CURABLE INK, AND IMAGE FORMATION PROCESS EMPLOYING THE SAME
  申请人：Sasa Nobumasa

  公开号：US20070123600A1

  公开（公告）日：2007-05-31

  Disclosed is an actinic ray curable composition comprising a cationically polymerizable compound, an onium salt, and a compound represented by formula 1, R 1 (CR 2 R 3 )mOH}n  Formula 1 wherein R 1 represents a condensed ring group; R 2 and R 3 independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; m represents an integer of from 2 to 4; and n represents an integer of from 1 to 10.
• US5519043A
  申请人：——

  公开号：US5519043A

  公开（公告）日：1996-05-21
• US7989517B2
  申请人：——

  公开号：US7989517B2

  公开（公告）日：2011-08-02
• Modular Tandem Mizoroki‐Heck/Reductive Heck Reactions to Construct Fluorenes from Cyclic Diaryliodoniums
  作者：Xiaopeng Peng、Yang Yang、Bingling Luo、Shijun Wen、Peng Huang

  DOI：10.1002/adsc.202001080

  日期：2021.1.5

  Starting from cyclic diaryliodoniums and terminal alkenes, a diverse set of fluorenes is conveniently constructed. The reactions catalyzed by palladium undergo one conventional Mizoroki‐Heck reaction and one reductive Heck reaction. The scope of alkenes is general, leading to 29 fluorenes which would expand the structural diversity of fluorene reservoir.

  从环状二芳基碘鎓和末端烯烃开始，可以方便地构建各种芴。钯催化的反应会进行一种常规的Mizoroki-Heck反应和一种还原性Heck反应。烯烃的范围很广，导致有29个芴，这将扩大芴储层的结构多样性。