N-(2,6-dimethylphenyl)-2-[4-(4-hydroxy-4-phenylbutyl)piperazin-1-yl]acetamide | 1082304-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: N-(2,6-dimethylphenyl)-2-[4-(4-hydroxy-4-phenylbutyl)piperazin-1-yl]acetamide
• CAS: 1082304-56-0
• 化学式: C₂₄H₃₃N₃O₂
• 分子量: 395.545
• InChiKey: OAMHIPWEVQNONQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSES HETEROCYCLIQUES SUBSTITUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2004063180A1

  公开（公告）日：2004-07-29

  Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.

  揭示了新颖的哌嗪衍生物，适用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常，间歇性跛行，普林兹梅塔（变异）心绞痛，稳定和不稳定心绞痛，运动诱发的心绞痛，充血性心力衰竭和心肌梗死。
• Substituted heterocyclic compounds
  申请人：——

  公开号：US20040176356A1

  公开（公告）日：2004-09-09

  Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.

  本发明涉及新颖的哌嗪衍生物，可用于治疗各种疾病状态，特别是心血管疾病，如房性和室性心律失常、间歇性跛行、普林兹梅塔尔（变异型）心绞痛、稳定和不稳定性心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死。
• Substituted Heterocyclic Compounds
  申请人：Palle Venkata

  公开号：US20070155728A1

  公开（公告）日：2007-07-05

  Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  本发明涉及一种新型杂环化合物，其结构如下，可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、间歇性跛行、普林兹梅塔尔（变异）心绞痛、稳定和不稳定心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死。这些化合物还可用于治疗糖尿病。
• SUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：Palle Venkata

  公开号：US20080275238A1

  公开（公告）日：2008-11-06

  Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  本发明涉及具有以下结构的新型杂环化合物，其可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常，间歇性跛行，普林兹梅塔尔（变异型）心绞痛，稳定和不稳定性心绞痛，运动诱发性心绞痛，充血性心力衰竭和心肌梗死。该化合物还可用于治疗糖尿病。
• US7205303B2
  申请人：——

  公开号：US7205303B2

  公开（公告）日：2007-04-17