| 1359987-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1359987-49-7
• 化学式: C₂₂H₃₈O₂Sn
• 分子量: 453.253
• InChiKey: ROZRPQHYKNESCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.99
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  在 cesium fluoride 作用下， 以 甲醇 、 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 60.0 ℃ 、100.0 kPa 条件下， 反应 4.0h， 生成 methyl 2-acetoxy-2-(2-methylphenyl)acetate
  参考文献：
  名称：

  Synthesis of Arylglycine and Mandelic Acid Derivatives through Carboxylations of α-Amido and α-Acetoxy Stannanes with Carbon Dioxide

  摘要：

  Incorporation reactions of carbon dioxide (CO2) with N-Boc-alpha\-amido and a-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected alpha-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. alpha-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of alpha-tertiary and alpha-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-alpha-amido stannanes was transferred with up to 90% inversion of configuration at 100 degrees C.

  DOI：

  10.1021/jo202597p
• 作为产物：
  描述：

  乙酰氯 、 2-甲基苯甲醛 、 ethyl(tri-n-butylstannyl)zinc 以 乙二醇二甲醚 为溶剂， 以54%的产率得到
  参考文献：
  名称：

  对映体富集的 α-（羟烷基）-三正丁基锡烷的合成。

  摘要：

  A catalytically asymmetric synthesis of α-(hydroxyalkyl)-tri-n-butylstannanes 1 in good-excellent yields and enantioselectivities (up to 98% e.e.) via addition of ethyl(tri-n-butylstannyl)zinc to aldehydes was achieved. In practice, 1 was isolated after protection as its more stable ester or thiocarbamate (PG). The reagent was prepared from equimolar amounts of tri-n-butylstannyl hydride and Et2Zn in DME so as to avoid contamination by lithium and magnesium ions which suppress enantioselectivity.

  DOI：

  10.1002/anie.200802313

文献信息

• JP5747740
  申请人：——

  公开号：——

  公开（公告）日：——