2-[4-(1-methylethoxy)phenyl]-1H-benzimidazole | 92965-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[4-(1-methylethoxy)phenyl]-1H-benzimidazole
• 英文别名: 2-(4-isopropoxyphenyl)-1H-benzo[d]imidazole；2-(4-isopropoxy-phenyl)-1H-benzimidazole；2-(4-Isopropoxy-phenyl)-1H-benzimidazol；2-(4-propan-2-yloxyphenyl)-1H-benzimidazole
• CAS: 92965-63-4
• 化学式: C₁₆H₁₆N₂O
• 分子量: 252.316
• InChiKey: MTLATYGCQJNGKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻苯二胺 、 4-异丙氧基苯甲醛 在 air 作用下， 以 甲醇 为溶剂， 以70%的产率得到2-[4-(1-methylethoxy)phenyl]-1H-benzimidazole
  参考文献：
  名称：

  苯并咪唑的可见光促进合成

  摘要：

  苯并咪唑由于具有多种生物学功能而在许多应用中是重要的结构基序，因此已经开发出一种简单且环境友好的苯并咪唑合成方法。邻苯二胺和各种脂肪族/芳香族醛在甲醇中的反应在室温下仅在天然来源、分子氧和可见光下进行。

  DOI：

  10.1002/ejoc.201402141

文献信息

• 2-arylbenzimidazoles as PPARGC1A activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10851066B2

  公开（公告）日：2020-12-01

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  公开了化合物 2-(3-叔丁基苯基)-4,6-二氟-1H-苯并[d]咪唑及其用途： 该化合物可激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-arylbenzimidazoles as Ppargc1a activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11111217B2

  公开（公告）日：2021-09-07

  The compound 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-5-ol: and its use are disclosed. The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  化合物 2-(4-叔丁基苯基)-1H-苯并[d]咪唑-5-醇： 及其用途。该化合物能激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200299244A1

  公开（公告）日：2020-09-24

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20210300877A1

  公开（公告）日：2021-09-30

  A genus of compounds encompassed by formula (III) and their use is disclosed: The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.
• [EN] 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES<br/>[FR] 2-ARYLBENZIMIDAZOLES UTILES EN TANT QU'ACTIVATEURS DE PPARGC1A POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2020033359A1

  公开（公告）日：2020-02-13

  A genus of compounds encompassed by formula (III) and their use is disclosed: Formula (III). The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.