cyclopropanesulfonic acid [(1S,3S,4R)-3-(2-difluoromethyl-imidazolo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl)-4-ethyl-cyclopentyl]-amide | 1310723-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: cyclopropanesulfonic acid [(1S,3S,4R)-3-(2-difluoromethyl-imidazolo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl)-4-ethyl-cyclopentyl]-amide
• 英文别名: cyclopropanesulfonic acid [(1S,3S,4R)-3-(2-difluoromethyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl)-4-ethyl-cyclopentyl]-amide；Cyclopropanesulfonic acid [(1S,3S,4R)-3-(2-difluoromethyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)-4-ethyl-cyclopentyl]-amide；N-[(1S,3S,4R)-3-[2-(difluoromethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl]-4-ethylcyclopentyl]-cyclopropanesulfonamide；N-[(1S,3S,4R)-3-[4-(difluoromethyl)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl]-4-ethylcyclopentyl]cyclopropanesulfonamide
• CAS: 1310723-20-6
• 化学式: C₁₉H₂₃F₂N₅O₂S
• 分子量: 423.487
• InChiKey: WQSLUOCDTHDLGI-ZETOZRRWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• NOVEL TRICYCLIC COMPOUNDS
  申请人：AbbVie Inc.

  公开号：US20210061813A1

  公开（公告）日：2021-03-04

  The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
• USRE47221E1
  申请人：——

  公开号：USRE47221E1

  公开（公告）日：2019-02-05