{2-[(10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester | 866325-24-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: {2-[(10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-[(4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]ethyl]carbamate
• CAS: 866325-24-8
• 化学式: C₂₃H₂₉N₃O₅
• 分子量: 427.5
• InChiKey: MQGGNOYCBFEUEG-UHFFFAOYSA-N

物化性质

• 沸点：
  733.8±60.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {2-[(10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester 在 C₆H₁₅NO₆S 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  基于杯芳烃的荧光比例温度探针†

  摘要：

  我们报告了第一个基于大环的比例式分子温度计，利用了用两个不同的荧光团官能化的杯芳烃的构象热敏性。由于温度依赖于有机荧光团之间的激发能传递效率，因此温度计可在60°C宽的温度范围内工作，灵敏度为4％C -1。

  DOI：

  10.1039/c9cc04577e
• 作为产物：
  描述：

  香豆素 343 在 草酰氯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 51.0h， 生成 {2-[(10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  基于杯芳烃的荧光比例温度探针†

  摘要：

  我们报告了第一个基于大环的比例式分子温度计，利用了用两个不同的荧光团官能化的杯芳烃的构象热敏性。由于温度依赖于有机荧光团之间的激发能传递效率，因此温度计可在60°C宽的温度范围内工作，灵敏度为4％C -1。

  DOI：

  10.1039/c9cc04577e

文献信息

• A FRET approach to phosgene detection
  作者：Hexiang Zhang、Dmitry M. Rudkevich

  DOI：10.1039/b614725a

  日期：——

  A FRET approach towards potential detection of phosgene is presented, which is based on a selective chemical reaction between phosgene (or triphosgene as a simulant) and donor and acceptor fluorophores.

  本研究提出了一种基于FRET的方法，用于潜在的光气检测，主要依赖于光气（或三光气作为模拟物）与供体和受体荧光团之间的选择性化学反应。
• Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna
  作者：Raymond P. Briñas、Thomas Troxler、Robin M. Hochstrasser、Sergei A. Vinogradov

  DOI：10.1021/ja052947c

  日期：2005.8.24

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.