2-(pyridyldisulfanyl)ethyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate | 1353545-90-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(pyridyldisulfanyl)ethyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate
• 英文别名: 2-(Pyridin-2-yldisulfanyl)ethyl 4-(benzenecarbonothioylsulfanyl)-4-cyanopentanoate
• CAS: 1353545-90-0
• 化学式: C₂₀H₂₀N₂O₂S₄
• 分子量: 448.655
• InChiKey: VHSXVXYBWCDGKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  171
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-(2-吡啶基二硫代)乙醇 、 4-氰基-4-(硫代苯甲酰)戊酸 在 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 40.0h， 以16%的产率得到2-(pyridyldisulfanyl)ethyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate
  参考文献：
  名称：

  Degradable thermoresponsive polymers which display redox-responsive LCST Behaviour

  摘要：

  通过RAFT衍生的末端官能大单体的聚缩聚，将二硫键引入聚（N-异丙基丙烯酰胺）中，得到了可降解但基于乙烯的聚合物。这些聚合物表现出红氧敏感的低临界溶解温度（LCST），且较短的降解产物的LCST高于其未降解对应物。

  DOI：

  10.1039/c1cc16323j

文献信息

• GLYCOTARGETING THERAPEUTICS
  申请人：École Polytechnique Fédérale de Lausanne (EPFL)

  公开号：US20170007708A1

  公开（公告）日：2017-01-12

  Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.
• [EN] GLYCOTARGETING THERAPEUTICS<br/>[FR] AGENTS THÉRAPEUTIQUES DE GLYCOCIBLAGE
  申请人：ECOLE POLYTECHNIQUE FED LAUSANNE EPFL

  公开号：WO2017046652A1

  公开（公告）日：2017-03-23

  Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.
• [EN] COMPOUNDS FOR THE INDUCTION OF ANTIGEN-SPECIFIC IMMUNE TOLERANCE<br/>[FR] COMPOSÉS POUR L'INDUCTION D'UNE TOLÉRANCE IMMUNITAIRE SPÉCIFIQUE D'UN ANTIGÈNE
  申请人：ANOKION SA

  公开号：WO2021053589A1

  公开（公告）日：2021-03-25

  Disclosed are compounds for the induction of antigen-specific immune tolerance in a subject, the compounds comprising an antigen, a polymeric linker and a liver targeting moiety, wherein the polymeric linker comprises a terminal end unit lacking each of a dithioester and a dithiobenzoate and wherein the terminal end unit confers improved stability to the compound when in solution.