2-(tert-butyl)-9-(di-p-tolylmethylene)-9H-fluorene | 1600505-77-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(tert-butyl)-9-(di-p-tolylmethylene)-9H-fluorene
• CAS: 1600505-77-8
• 化学式: C₃₂H₃₀
• 分子量: 414.59
• InChiKey: SLGJMEJSEHHVNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.59
• 重原子数：
  32.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  3-(2-methylpropan-1-ylium-2-yl)dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate 、 4-甲苯硼酸 、 4-甲苯基乙炔 在 copper(l) iodide 、 palladium diacetate 、 sodium carbonate 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以55%的产率得到2-(tert-butyl)-9-(di-p-tolylmethylene)-9H-fluorene
  参考文献：
  名称：

  Three-Component Pd/Cu-Catalyzed Cascade Reactions of Cyclic Iodoniums, Alkynes, and Boronic Acids: An Approach to Methylidenefluorenes

  摘要：

  Linear diaryliodonium salts are widely used as arylating reagents for C-C and C-X bond formation. Meanwhile, synthetic applications of cyclic iodoniums are relatively rare although they offer the opportunity to set up reaction cascades. We demonstrate an atom and step economical three-component reaction involving cyclic diphenyleneiodoniums, alkynes, and boronic acids, resulting in the construction of methylidenefluorenes in a single operation. Our route enables facile access to both symmetrical and unsymmetrical methylidenefluorene derivatives, compounds that have attracted interest due to their optical properties.

  DOI：

  10.1021/ol5006714