6-salicyloylhydrazono-6-deoxy-L-gulonic acid | 92109-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-salicyloylhydrazono-6-deoxy-L-gulonic acid
• 英文别名: 6-Salicyloylhydrazono-6-desoxy-L-gulonsaeure
• CAS: 92109-67-6
• 化学式: C₁₃H₁₆N₂O₈
• 分子量: 328.279
• InChiKey: ZJSFVODGPMFUSX-VLEAKVRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.36
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  179.91
• 氢给体数：
  7.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  D-葡萄糖醛酸 、 水杨酰肼 生成 6-salicyloylhydrazono-6-deoxy-L-gulonic acid
  参考文献：
  名称：

  Identification of drug-resistantMycobacterium tuberculosis by single strand conformation polymorphism and cleavase fragment length polymorphism

  摘要：

  Twenty isolates ofMycobacterium tuberculosis resistant to rifampicin(RIF), isoniazid(INH) and streptomycin(STR) were analysed by Polymerase Chain Reaction (PCR) amplification of rpoB, katG and rrs genes to evaluate comparative diagnostic significance of genetic assays. Mutations were identified by single strand conformation polymorphism (SSCP) and cleavase fragment length polymorphism (CFLP) and were confirmed by DNA sequencing. SSCP of 4 RIF resistant and 14 INH resistant isolates showed an extra peak at the level of 75-bp and 85-bp respectively, while 2 STR resistant isolates showed 2 peaks with 9 bases difference. CFLP showed a different pattern among RIF, INH and STR sensitive and resistant isolates Thus SSCP and CFLP can be used as alternative diagnostic methods for identification of mutations in RIF, INH and STR resistant strains of M.tuberculosis.

  DOI：

  10.1007/bf02883734