N-[3-[[[2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamide | 1160213-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-[3-[[[2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamide
• CAS: 1160213-04-6
• 化学式: C₂₅H₂₈F₃N₇O₅S
• 分子量: 595.602
• InChiKey: BMMOSRMQIZHJHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• [EN] DIAMINOPYRIDINES FOR THE TREATMENT OF DISEASES WHICH ARE CHARACTERISED BY EXCESSIVE OR ANOMAL CELL PROLIFERATION<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009071535A1

  公开（公告）日：2009-06-11

  The present invention encompasses compounds of general formula (1) wherein A, B, R1- R3, Rx and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中A，B，R1-R3，Rx和n如权利要求1中所定义的化合物，适用于治疗由过度或异常细胞增殖特征的疾病，并且它们用于制备具有上述特性的药物。
• DIAMINOPYRIDINES FOR THE TREATMENT OF DISEASES WHICH ARE CHARACTERISED BY EXCESSIVE OR ANOMAL CELL PROLIFERATION
  申请人：Sapountzis Ioannis

  公开号：US20100305099A1

  公开（公告）日：2010-12-02

  The present invention encompasses compounds of general formula (1) wherein A, B, R 1 -R 3 , Rx and n are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中A、B、R1-R3、Rx和n如权利要求1所定义的化合物，适用于治疗由过度或异常细胞增殖所特征的疾病，并且它们的用途用于制备具有上述特性的药物。
• US8461147B2
  申请人：——

  公开号：US8461147B2

  公开（公告）日：2013-06-11