2-amino-4-methyl-8-((3S)-tetrahydrofuran-3-yl)-6-(1,3-thiazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one | 1071829-62-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-amino-4-methyl-8-((3S)-tetrahydrofuran-3-yl)-6-(1,3-thiazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
• 英文别名: 2-amino-4-methyl-8-[(3S)-oxolan-3-yl]-6-(1,3-thiazol-5-yl)pyrido[2,3-d]pyrimidin-7-one
• CAS: 1071829-62-3
• 化学式: C₁₅H₁₅N₅O₂S
• 分子量: 329.382
• InChiKey: OCSCOUYGARUHSP-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Composition for low dielectric material, low dielectric material and method for production thereof
  申请人：Kumada Teruhiko

  公开号：US20050282015A1

  公开（公告）日：2005-12-22

  A low dielectric material is produced by using a composition including a borazine ring-containing compound and a compound represented by the following formula as a solvent, and/or by annealing a composition comprising a borazine ring-containing compound under atmosphere of oxygen concentration not higher than 0.1 vol % at 200 to 600° C. In the following formula, R a and R c independently represent alkyl group or acyl group; R b represents hydrogen atom or alkyl group; and n represents an integer of 1 to 5.

  使用含有硼氮杂环化合物和下式所示化合物的组合物作为溶剂，和/或在氧浓度不高于0.1体积%的气氛下，在200至600°C的条件下退火含有硼氮杂环化合物的组合物，可以制备出低介电常数材料。在下式中，Ra和Rc分别表示烷基或酰基；Rb表示氢原子或烷基；n表示1至5的整数。
• COMPOSITION FOR LOW DIELECTRIC MATERIAL, LOW DIELECTRIC MATERIAL AND METHOD FOR PRODUCTION THEREOF
  申请人：KUMADA Teruhiko

  公开号：US20090090274A1

  公开（公告）日：2009-04-09

  A low dielectric material is produced by using a composition including a borazine ring-containing compound and a compound represented by the following formula as a solvent, and/or by annealing a composition comprising a borazine ring-containing compound under atmosphere of oxygen concentration not higher than 0.1 vol % at 200 to 600° C. In the following formula, R a and R c independently represent alkyl group or acyl group; R b represents hydrogen atom or alkyl group; and n represents an integer of 1 to 5.

  使用包含硼氮杂环化合物和下列公式所代表的化合物作为溶剂的组合物，和/或在氧气浓度不高于0.1体积%的气氛下，在200至600°C下退火含有硼氮杂环化合物的组合物，可以制备出低介电常数材料。在下面的公式中，Ra和Rc分别代表烷基或酰基；Rb代表氢原子或烷基；n表示1到5的整数。
• PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF P13K-ALPHA FOR THE TREATMENT OF CANCER
  申请人：Buhr Chris A.

  公开号：US20100209340A1

  公开（公告）日：2010-08-19

  The invention is directed to Compounds of Formula (I). The invention provides compounds that inhibit, regulate, and/or modulate P13K that are useful in the treatment of hyperproliferative diseases, such as cancer.

  该发明涉及式(I)化合物。该发明提供了抑制、调节和/或调控P13K的化合物，这些化合物在治疗高增殖性疾病，如癌症方面是有用的。
• Pyrido [2, 3-D] pyrimidin-7-one compounds as inhibitors of P13K-Alpha for the treament of cancer
  申请人：Exelixis, Inc.

  公开号：US20130343988A1

  公开（公告）日：2013-12-26

  The invention is directed to Compounds of Formula (I). The invention provides compounds that inhibit, regulate, and/or modulate P13K that are useful in the treatment of hyperproliferative diseases, such as cancer.

  本发明涉及式(I)的化合物。本发明提供抑制、调节和/或调节P13K的化合物，这些化合物在治疗过度增殖性疾病，如癌症方面是有用的。
• PYRIDO [2, 3-D]PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF PI3K-ALPHA FOR THE TREATMENT OF CANCER
  申请人：Exelixis, Inc.

  公开号：EP2142544B1

  公开（公告）日：2013-05-22