1-[3-(5-bromo-3-nitropyridin-2-ylamino)phenyl]pyrrolidin-2-one | 329280-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-[3-(5-bromo-3-nitropyridin-2-ylamino)phenyl]pyrrolidin-2-one
• 英文别名: 1-[3-[(5-bromo-3-nitropyridin-2-yl)amino]phenyl]pyrrolidin-2-one
• CAS: 329280-75-3
• 化学式: C₁₅H₁₃BrN₄O₃
• 分子量: 377.197
• InChiKey: OYTSOBDKGBCUGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[3-(5-bromo-3-nitropyridin-2-ylamino)phenyl]pyrrolidin-2-one 、 、 乙醇 生成 1-[3-(6-bromo-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]pyrrolidin-2-one
  参考文献：
  名称：

  Imidazo-pyridine derivatives as ligands for GABA receptors

  摘要：

  本发明涉及选择性GABAA受体配体的3-苯基咪唑并[4,5-b]吡啶衍生物。这些化合物可用于治疗和预防中枢神经系统疾病，包括焦虑和抽搐。

  公开号：

  US06723735B1
• 作为产物：
  描述：

  5-溴-2-氯-3-硝基吡啶 、 1-(3-氨基苯)吡咯烷-2-酮 在 potassium carbonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 60.0h， 以68%的产率得到1-[3-(5-bromo-3-nitropyridin-2-ylamino)phenyl]pyrrolidin-2-one
  参考文献：
  名称：

  IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

  摘要：

  公开号：

  EP1214319B1

文献信息

• Niacinamide, niacin, and niacin esters based delivery systems for treating topical disorders of skin and skin aging
  申请人：——

  公开号：US20040081672A1

  公开（公告）日：2004-04-29

  The present invention relates to application of niacinamide, niacin, and niacin esters (nicotinic acid esters) derivatives of skin beneficial organic acids (henceforth called “derivatives”) for the synergistic treatment or prevention of topical disorders of skin such as acne, rosacea, skin wrinkles, age-spots, canker sores, striae distensae (stretch marks), pimples, and skin redness. These “derivatives” are made by a very simple in-situ method. These “derivatives” provide enhanced bioavailability of both ingredients that are combined to form such derivatives. The “derivatives” of present invention can be formulated in a wide variety of delivery systems including traditional water and oil emulsions, suspensions, colloids, solutions, or anhydrous systems. Niacin and certain niacin ester derivatives prepared by the in-situ method are free of flushing effect (a warm feeling in the skin usually associated with redness and itching) normally experienced with niacin and certain niacin esters themselves.
• US6723735B1
  申请人：——

  公开号：US6723735B1

  公开（公告）日：2004-04-20
• [EN] IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-PYRIDINE EN TANT QUE LIGANDS DESTINES AUX RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2001018000A1

  公开（公告）日：2001-03-15

  A class of 3-phenylimidazo[4,5-b]pyridine derivatives, substituted at the meta position of the phenyl ring by a range of substituents, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
• IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：Merck Sharp & Dohme Limited

  公开号：EP1214319B1

  公开（公告）日：2003-11-26
• Imidazo-pyridine derivatives as ligands for GABA receptors
  申请人：Merck Sharp & Dohme Ltd.

  公开号：US06723735B1

  公开（公告）日：2004-04-20

  The present invention is directed to 3-phenylimidazol[4,5-b]pyridine derivatives, that are selective ligands for GABAA receptors. These compounds are useful in the treatment and prevention of disorders of the central nervous system, including anxiety and convulsions.

  本发明涉及选择性GABAA受体配体的3-苯基咪唑并[4,5-b]吡啶衍生物。这些化合物可用于治疗和预防中枢神经系统疾病，包括焦虑和抽搐。