4-phenyl-1-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-3-carboxamide | 1553980-30-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-phenyl-1-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-3-carboxamide
• 英文别名: 4-Phenyl-1-pyrrolo[2,1-f][1,2,4]triazin-4-ylpyrrole-3-carboxamide
• CAS: 1553980-30-5
• 化学式: C₁₇H₁₃N₅O
• 分子量: 303.323
• InChiKey: BMTDEJAZFFSOIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted pyrroles active as kinases inhibitors
  申请人：NERVIANO MEDICAL SCIENCES S.r.l.

  公开号：US10479779B2

  公开（公告）日：2019-11-19

  The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

  本发明涉及取代的吡咯化合物，该化合物可调节蛋白激酶的活性，因此可用于治疗由蛋白激酶活性失调（尤其是 Jak 家族激酶）引起的疾病。本发明还提供了制备这些化合物的方法、含有这些化合物的药物组合物，以及利用这些化合物或含有这些化合物的药物组合物治疗疾病的方法。
• SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.r.l.

  公开号：US20180339978A1

  公开（公告）日：2018-11-29

  The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.