2-(4-propoxyphenyl)-1H-benzo[d]imidazole | 92965-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-propoxyphenyl)-1H-benzo[d]imidazole
• 英文别名: 2-(4-propoxyphenyl)-1H-benzimidazole
• CAS: 92965-64-5
• 化学式: C₁₆H₁₆N₂O
• 分子量: 252.316
• InChiKey: AGSYKXRBABATDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-丙氧基苯甲醛 在 乙醇 、 硝基苯 作用下， 生成 2-(4-propoxyphenyl)-1H-benzo[d]imidazole
  参考文献：
  名称：

  Profft et al., Journal fur praktische Chemie (Leipzig 1954), 1955, vol. <4> 1, p. 110,121

  摘要：

  DOI：

文献信息

• Molecularly Engineering Defective Basal Planes in Molybdenum Sulfide for the Direct Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes
  作者：Miriam Rodenes、Francisco Gonell、Santiago Martín、Avelino Corma、Iván Sorribes

  DOI：10.1021/jacsau.1c00477

  日期：2022.3.28

  compounds in a less costly, compact, and greener manner from cheap and readily available reagents is highly desirable in modern synthetic chemistry. Herein, we report a straightforward synthesis of benzimidazoles by reductive coupling of o-dinitroarenes with aldehydes in the presence of molecular hydrogen. An innovative molecular cluster-based synthetic strategy that employs Mo3S4 complexes as precursors

  现代合成化学非常需要开发更可持续的催化工艺，以更便宜、更紧凑、更环保的方式从廉价且易于获得的试剂制备 N-杂环化合物。在此，我们报告了在分子氢存在下通过邻二硝基芳烃与醛的还原偶联直接合成苯并咪唑。采用 Mo 3 S 4配合物作为前体的基于分子簇的创新合成策略已被用于设计缺硫二硫化钼 (MoS 2) 型材料在自然发生的边缘位置和沿典型的非活动基面显示结构缺陷。通过应用这种催化剂，即使在存在氢化敏感官能团（如双碳-碳键和三碳-碳键）的情况下，也可以通过这种直接氢化偶联方案选择性合成多种功能化的 2-取代苯并咪唑，包括生物活性化合物、腈和酯基团、卤素以及各种类型的杂芳烃。
• 2-arylbenzimidazoles as PPARGC1A activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10851066B2

  公开（公告）日：2020-12-01

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  公开了化合物 2-(3-叔丁基苯基)-4,6-二氟-1H-苯并[d]咪唑及其用途： 该化合物可激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-arylbenzimidazoles as Ppargc1a activators for treating neurodegenerative diseases
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11111217B2

  公开（公告）日：2021-09-07

  The compound 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-5-ol: and its use are disclosed. The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.

  化合物 2-(4-叔丁基苯基)-1H-苯并[d]咪唑-5-醇： 及其用途。该化合物能激活 Ppargc1a，因此可用于治疗神经炎症和各种神经退行性疾病。
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200299244A1

  公开（公告）日：2020-09-24

  The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.
• 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20210300877A1

  公开（公告）日：2021-09-30

  A genus of compounds encompassed by formula (III) and their use is disclosed: The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.