4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl cyanate | 251462-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl cyanate
• 英文别名: [4-(2,5-dioxopyrrol-1-yl)phenyl] cyanate
• CAS: 251462-34-7
• 化学式: C₁₁H₆N₂O₃
• 分子量: 214.18
• InChiKey: KISXEYFYGOSMSK-UHFFFAOYSA-N

物化性质

• 沸点：
  379.9±44.0 °C(Predicted)
• 密度：
  1.450±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• HAPTENS OF ARIPIPRAZOLE AND THEIR USE IN IMMUNOASSAYS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3321254A1

  公开（公告）日：2018-05-16

  The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

  本发明涉及式 I 化合物，其中 R1、R2 和 R3 在说明书中定义，可用于合成由阿立哌唑衍生的新型共轭物和免疫原。本发明还涉及阿立哌唑合剂与蛋白质的共轭物。
• STABLE FC BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT IN WHICH SAID PROTEIN IS USED
  申请人：Tosoh Corporation

  公开号：EP3617315A1

  公开（公告）日：2020-03-04

  The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid.

  本发明要解决的问题是提供对热和酸具有更好稳定性的 FcRn、生产所述 FcRn 的方法、使用所述 FcRn 的抗体吸附剂以及使用所述吸附剂的抗体分离方法。解决上述问题的方法是用另一种特定氨基酸取代人 FcRn α 链细胞外区域和/或人 FcRn β 链β2 微球蛋白区域中特定位置的氨基酸残基。
• Haptens of aripiprazole
  申请人：Janssen Pharmaceutica NV

  公开号：US10166296B2

  公开（公告）日：2019-01-01

  The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

  本发明涉及式 I 化合物，其中 R1、R2 和 R3 在说明书中定义，可用于合成由阿立哌唑衍生的新型共轭物和免疫原。本发明还涉及阿立哌唑合剂与蛋白质的共轭物。
• Antibodies to paliperidone haptens and use thereof
  申请人：Janssen Pharmaceutica NV

  公开号：US10370457B2

  公开（公告）日：2019-08-06

  Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, risperidone and paliperidone in a single lateral flow assay device.

  本发明公开了一种与帕潘立酮结合的抗体，可用于检测样品中的帕潘立酮，如竞争性免疫分析法。该抗体可用于横向流动检测装置，进行帕利哌酮的床旁检测，包括在单个横向流动检测装置中对阿立哌唑、奥氮平、喹硫平、利培酮和帕利哌酮进行多重检测。
• Antibodies to aripiprazole haptens and use thereof
  申请人：Janssen Pharmaceutica NV

  公开号：US10379105B2

  公开（公告）日：2019-08-13

  Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

  本发明公开了一种与阿立哌唑结合的抗体，可用于检测样品中的阿立哌唑，如竞争性免疫分析法。该抗体可用于横向流动检测装置，进行阿立哌唑的床旁检测，包括在单个横向流动检测装置中对阿立哌唑、奥氮平、喹硫平和利培酮进行多重检测。