2,2,5,5-tetramethylthiazolidine-4S-carboxylic acid hydrochloride | 17266-78-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2,5,5-tetramethylthiazolidine-4S-carboxylic acid hydrochloride
• 英文别名: (S)-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid ; hydrochloride；(S)-2,2,5,5-Tetramethyl-thiazolidin-4-carbonsaeure; Hydrochlorid；(4S)-2,2,5,5-tetramethyl-1,3-thiazolidin-3-ium-4-carboxylic acid;chloride
• CAS: 17266-78-3
• 化学式: C₈H₁₅NO₂S*ClH
• 分子量: 225.74
• InChiKey: YNSAPAAAKBYKQC-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  74.6
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-苯基苯甲酰氯 、 2,2,5,5-tetramethylthiazolidine-4S-carboxylic acid hydrochloride 在 吡啶 作用下， 以74%的产率得到2,2,5,5-tetramethyl-3-o-phenylbenzoylthiazolidine-4S-carboxylic acid
  参考文献：
  名称：

  Memory of Chirality in the Electrochemical Oxidation of Thiazolidine-4-carboxylic Acid Derivatives

  摘要：

  Memory of chirality in the electrochemical oxidation of thiazolidine-4-carboxylic acid derivatives was observed. The relatively larger size of sulphur atom than the oxygen atom for oxazolidine-4-carboxylic acid derivative may slightly improved the enantioselectivities of the oxidized products. The bulkier penicillamine derivative 1c furnished 2c with much better enantioselectivity (91% ee) than that of the cysteine derivative 2b (85% ee). The presence of two extra dimethyl groups, for the penicillamine derivative improved the enantioselectivities of the thiazolidine derivatives from 85% ee to 91% ee.

  DOI：

  10.3987/com-09-s(s)101

文献信息

• Memory of Chirality in the Electrochemical Oxidation of Thiazolidine-4-carboxylic Acid Derivatives
  作者：Osamu Onomura、George Ng’aNg’a Wanyoike、Yoshihiro Matsumura、Masami Kuriyama

  DOI：10.3987/com-09-s(s)101

  日期：——

  Memory of chirality in the electrochemical oxidation of thiazolidine-4-carboxylic acid derivatives was observed. The relatively larger size of sulphur atom than the oxygen atom for oxazolidine-4-carboxylic acid derivative may slightly improved the enantioselectivities of the oxidized products. The bulkier penicillamine derivative 1c furnished 2c with much better enantioselectivity (91% ee) than that of the cysteine derivative 2b (85% ee). The presence of two extra dimethyl groups, for the penicillamine derivative improved the enantioselectivities of the thiazolidine derivatives from 85% ee to 91% ee.