2-(iodomethyl)-1,4-dimethylbenzene | 1132842-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(iodomethyl)-1,4-dimethylbenzene
• CAS: 1132842-33-1
• 化学式: C₉H₁₁I
• 分子量: 246.091
• InChiKey: KDICROKHKZEUCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-(iodomethyl)-1,4-dimethylbenzene 、 吡啶, 2-[(二氟甲基)磺酰基]- 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 为溶剂， 反应 0.08h， 以99%的产率得到2-(2-(2,5-dimethylphenyl)-1,1-difluoroethylsulfonyl)pyridine
  参考文献：
  名称：

  从二氟甲基2-吡啶基砜到二氟化磺酸盐：亲核性二氟（磺酰基）甲基化的方案

  摘要：

  已开发出一种合成α，α-二氟磺酸烷基酯的有效方法。选择2-吡啶基作为砜上的芳基取代基对于成功实现这种转化至关重要（请参见方案）。氟化砜的合成应用得到了扩展，并提供了独特的解决方案来应对亲核性二氟（磺酰基）甲基化反应中的长期挑战。

  DOI：

  10.1002/anie.201007594

文献信息

• BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS
  申请人：Glick Gary D.

  公开号：US20090118244A1

  公开（公告）日：2009-05-07

  The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.

  本发明提供了一类苯二氮卓酮化合物及其药物组合物。本发明还提供了治疗某些皮肤病症的方法，例如特应性皮炎、酒渣鼻或银屑病，通过给予苯二氮卓酮以及通过将角质细胞暴露于苯二氮卓酮来减少角质细胞增殖的方法。
• [EN] BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME<br/>[FR] COMPOSÉS DE BENZODIAZÉPINONE ET MÉTHODES DE TRAITEMENT LES UTILISANT
  申请人：UNIV MICHIGAN

  公开号：WO2011035124A1

  公开（公告）日：2011-03-24

  The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

  该发明提供了1,4-苯并二氮杂酮化合物、药物组合物以及治疗自身免疫性疾病、慢性炎症性疾病和过度增殖性疾病的方法。例如，这些1,4-苯并二氮杂酮化合物和药物组合物被认为对治疗类风湿关节炎、移植物抗宿主病、炎症性肠病等疾病有用。
• BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME
  申请人：Glick Gary D.

  公开号：US20120232067A1

  公开（公告）日：2012-09-13

  The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

  本发明提供了1,4-苯二氮卓酮类化合物、制药组合物以及治疗自身免疫性疾病、慢性炎症性疾病和过度增生性疾病的方法。例如，考虑到1,4-苯二氮卓酮类化合物和制药组合物可用于治疗类风湿性关节炎、移植物抗宿主病、炎症性肠病等疾病。
• CHOLESTERIC LIQUID CRYSTAL MIXTURE, FILM, INFRARED REFLECTING PLATE, LAMINATED ARTICLE, AND LAMINATED GLASS
  申请人：Fujifilm Corporation

  公开号：EP2832821A1

  公开（公告）日：2015-02-04

  A cholesteric liquid crystal mixture containing a compound represented by formula (Ia) : Z1-Y1-A1-Y3-M1-Y4-A2-Y2-Z2, a compound represented by formula (Ib) : Z3-Y5-A3-Y7-M2-P, and a tri- or higher functional polymerizable monomer suppresses deposition of a liquid crystal at the time of forming a film, exhibits a wide characteristic reflection bandwidth of a film to be obtained, and suppresses change of a reflection bandwidth caused when laminated glass is manufactured by laminating a liquid crystal film obtained by fixing a cholesteric liquid crystal phase of the film to be obtained with an interlayer film. Z1, Z2 and Z3 represent a polymerizable group; A1, A2 and A3 represent a spacer having an atom-bonding chain length of 1 to 30, provided that the spacer represents an alkylene group, or a linking group of multiple alkylene groups bonding to each other via -O- or -CO-; M1 and M2 represent (-T1-Y8)n-T2-; n indicates a natural number; when n is 2 or more, multiple (-T1-Y8)'s may be the same or different; T1 and T2 represent a saturated or unsaturated hydrocarbon ring, or a saturated or unsaturated heterocyclic ring, provided that the hydrocarbon ring and the heterocyclic ring may have a substituent; Y1, Y2, Y3, Y4, Y5, Y7 and Y8 each independently represent a single bond, -O-, -CO-, -O-CO-, -CO-O- or -O-CO-O-; and P represents a hydrogen atom or an alkyl group having 1 to 15 carbon atoms.

  一种胆甾型液晶混合物，含有由式 (Ia) ：Z1-Y1-A1-Y3-M1-Y4-A2-Y2-Z2、由式 (Ib) ：Z3-Y5-A3-Y7-M2-P，以及一种三官能团或更高官能团的可聚合单体，可抑制成膜时液晶的沉积，使获得的薄膜具有较宽的特性反射带宽，并可抑制通过将获得的薄膜的胆甾液晶相固定而获得的液晶薄膜与中间膜层压而制造层压玻璃时引起的反射带宽变化。Z1、Z2 和 Z3 代表可聚合基团；A1、A2 和 A3 代表原子键合链长度为 1 至 30 的间隔物，条件是间隔物代表亚烷基，或通过 -O- 或 -CO- 相互键合的多个亚烷基的连接基团；M1 和 M2 代表 (-T1-Y8)n-T2-；n 表示自然数；当 n 为 2 或更多时，多个 (-T1-Y8) 可以相同或不同；T1和T2代表饱和或不饱和烃环，或饱和或不饱和杂环，条件是烃环和杂环可以具有取代基；Y1、Y2、Y3、Y4、Y5、Y7和Y8各自独立地代表单键、-O-、-CO-、-O-CO-、-CO-O-或-O-CO-O-；P代表氢原子或具有1至15个碳原子的烷基。
• SUBSTITUTED PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
  申请人：Bayer HealthCare LLC

  公开号：EP1751139B1

  公开（公告）日：2011-07-27