N-benzene-sulfonyl-N'-phenyl-N'-ethoxycarbonylmethylthiourea | 177712-12-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzene-sulfonyl-N'-phenyl-N'-ethoxycarbonylmethylthiourea
• 英文别名: ethyl 2-[N-(benzenesulfonylcarbamothioyl)anilino]acetate
• CAS: 177712-12-8
• 化学式: C₁₇H₁₈N₂O₄S₂
• 分子量: 378.473
• InChiKey: JWTOQNWOBDNDLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
  申请人：SUNTORY LIMITED

  公开号：EP0721944A1

  公开（公告）日：1996-07-17

  The invention relates to an imidazolidine derivative represented by the following general formula (1): wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C1-4 alkyl groups, C1-4 alkoxy groups, C1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.

  本发明涉及一种由以下通式（1）代表的咪唑烷衍生物： 其中 A 和 B 分别指可被 1-3 个取代基取代的芳香烃基团，这些取代基选自卤素原子、C1-4 烷基、C1-4 烷氧基、C1-4 亚烷氧基、苯氧基、硝基、氰基、苯基、C2-5 烷氨基、可与 C1-4 烷基或烯基酯化的羧基、可与 C1-4 烷基或烯基酯化的羧烷基、可与 C1-4 烷基或烯基酯化的羧烷基、可与 C1-4 烷基或烯基酯化的羧烷基、可与 C1-4 烷基或烯基酯化的羧烷基、可与 C1-4 烷基或烯基酯化的羧烷基、可与 C1-4 烷基或烯基酯化的羧基烷基、可与 C1-4 烷基或烯基酯化的羧基烷氧基、N-烷基哌嗪基羰基、N-烷基哌嗪基羰基烷基、N-烷基哌嗪基羰基烷氧基和吗啉基羰基；X 表示磺酰基或羰基；Y 表示氧原子或硫原子，包括作为活性成分的糜蛋白酶抑制剂，以及包括作为活性成分的药物，典型的是用于预防和治疗血管紧张素 II 异常加速分泌引起的心脏或循环系统疾病的药物。
• US5691335A
  申请人：——

  公开号：US5691335A

  公开（公告）日：1997-11-25