4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine dihydrochloride | 265654-78-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine dihydrochloride
• 英文别名: 4-(2-pyrrolidin-1-ylethoxy)aniline;dihydrochloride
• CAS: 265654-78-2
• 化学式: C12H20Cl2N2O
• 分子量: 279.2
• InChiKey: JUAMWUMLDDQOSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Compositions and methods for treating myelofibrosis
  申请人：Impact Biomedicines, Inc.

  公开号：US10391094B2

  公开（公告）日：2019-08-27

  Provided herein are compositions and methods for treating myelofibrosis in a subject. The methods comprise administering to the subject an effective amount of compound which is which is N-tert-butyl-3-[(5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide or a pharmaceutical salt thereof or a hydrate thereof.

  本文提供了用于治疗受试者骨髓纤维化的组合物和方法。这些方法包括向受试者施用有效量的化合物，该化合物是N-叔丁基-3-[(5-甲基-2-[4-(2-吡咯烷-1-基乙氧基)苯基]氨基}嘧啶-4-基)氨基]苯磺酰胺或其药物盐或其水合物。
• COMPOSITIONS AND METHODS FOR TREATING MYELOFIBROSIS
  申请人：TARGEGEN, INC.

  公开号：US20130252988A1

  公开（公告）日：2013-09-26

  Provided herein are compositions and methods for treating myelofibrosis in a subject. The methods comprise administering to the subject an effective amount of compound which is which is N-tert-butyl-3-[(5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide or a pharmaceutical salt thereof or a hydrate thereof.