N-(1,3-dihydroxy-2-methylpropan-2-yl)-4-methylbenzenesulfonamide | 91341-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1,3-dihydroxy-2-methylpropan-2-yl)-4-methylbenzenesulfonamide
• 英文别名: N-(2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-toluene-4-sulfonamide；N-(2-Hydroxy-1-hydroxymethyl-1-methyl-aethyl)-toluol-4-sulfonamid；2-Methyl-2-p-toluolsulfonamidopropan-1,3-diol
• CAS: 91341-16-1
• 化学式: C₁₁H₁₇NO₄S
• mdl: MFCD01166331
• 分子量: 259.326
• InChiKey: ODWXTDNJUJLHAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲苯磺酰氯 、 2-氨基-2-甲基-1,3-丙二醇 在 sodium carbonate 作用下， 以 异丙醇 为溶剂， 生成 N-(1,3-dihydroxy-2-methylpropan-2-yl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Hypoglycaemic Agents. Part III

  摘要：

  描述了托布唑胺的新变体。

  DOI：

  10.1111/j.2042-7158.1962.tb11132.x

文献信息

• Enantioselective Synthesis of α-Substituted Serine Derivatives via Cu-Catalyzed Oxidative Desymmetrization of 2-Amino-1,3-diols
  作者：Kosuke Yamamoto、Shota Ishimaru、Tatsuya Oyama、Satoko Tanigawa、Masami Kuriyama、Osamu Onomura

  DOI：10.1021/acs.oprd.8b00407

  日期：2019.4.19

  The enantioselective copper-catalyzed oxidative desymmetrization for the synthesis of chiral α-substituted serine derivatives is reported. The combination of Cu(OTf)2/(R,R)-PhBOX catalyst system, N-bromosuccinimide, and MeOH enables us to provide chiral α-substituted serines from N-2-methylbenzoyl-protected 2-amino-1,3-diols through a simple procedure at room temperature under an air atmosphere. A

  报道了用于手性α-取代的丝氨酸衍生物的合成的对映选择性铜催化的氧化脱对称。Cu（OTf）2 /（R，R）-PhBOX催化剂体系，N-溴琥珀酰亚胺和MeOH的组合使我们能够从N -2-甲基苯甲酰基保护的2-氨基-1,3-提供手性α-取代的丝氨酸室温下在大气气氛下通过简单的步骤制备二醇。该方法可耐受包括芳基和杂芳基在内的多种α-取代基，并以高至高收率和高对映选择性获得了相应的手性丝氨酸衍生物。
• MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS
  申请人：HADIDA RUAH SARA S.

  公开号：US20090143381A1

  公开（公告）日：2009-06-04

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药用可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节蛋白（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• Modulators of ATP-binding cassette transporters
  申请人：Ruah Sara S. Hadida

  公开号：US20080113985A1

  公开（公告）日：2008-05-15

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Hadida Ruah Sara S.

  公开号：US20080306062A1

  公开（公告）日：2008-12-11

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• Modulators of ATP-Binding Cassette Transporters
  申请人：Hadida Ruah Sara S.

  公开号：US20120322798A1

  公开（公告）日：2012-12-20

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组成物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTC”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。