1-(Fluoromethyl)cyclobutane-1-carboxylic acid | 1553867-84-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(Fluoromethyl)cyclobutane-1-carboxylic acid
• CAS: 1553867-84-7
• 化学式: C₆H₉FO₂
• 分子量: 132.13
• InChiKey: AGPYMWSEOIOIPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF FLUOROHALOALKANES
  申请人：Hammersmith Imanet, Ltd

  公开号：EP1554231A2

  公开（公告）日：2005-07-20
• [EN] PROCESS FOR THE PREPARATION OF FLUOROHALOALKANES<br/>[FR] PROCEDE CHIMIQUE
  申请人：HAMMERSMITH IMANET LTD

  公开号：WO2004029006A2

  公开（公告）日：2004-04-08

  The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R', R', and R'' are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R'' may alternatively be the group, with a compound of formula (III), wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.