METHODS OF PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS
申请人:ALIOS BIOPHARMA, INC.
公开号:US20130253181A1
公开(公告)日:2013-09-26
Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
[EN] METHODS OF STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED NUCLEOSIDE ANALOGS<br/>[FR] MÉTHODES DE SYNTHÈSE STÉRÉOSÉLECTIVE D'ANALOGUES NUCLÉOSIDIQUES SUBSTITUÉS
申请人:VERTEX PHARMA
公开号:WO2014164533A8
公开(公告)日:2015-07-23
[EN] SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG<br/>[FR] FORMES SOLIDES D'UN PROMÉDICAMENT NUCLÉOTIDIQUE THIOPHOSPHORAMIDATE
申请人:VERTEX PHARMA
公开号:WO2013142124A8
公开(公告)日:2014-05-15
PHARMACEUTICAL COMBINATIONS COMPRISING A THIONUCLEOTIDE ANALOG
申请人:ALIOS BIOPHARMA, INC.
公开号:US20130252920A1
公开(公告)日:2013-09-26
Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases and/or conditions with a pharmaceutical composition that can include a thionucleotide analog in combination therapy with other agents.
Solid Forms of a Thiophosphoramidate Nucleotide Prodrug
申请人:Vertex Pharmaceuticals Incorporated
公开号:US20130266538A1
公开(公告)日:2013-10-10
The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.