N-([1,1'-Biphenyl]-3-yl)-2,6-dibromopyridin-4-amine | 920752-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-([1,1'-Biphenyl]-3-yl)-2,6-dibromopyridin-4-amine
• 英文别名: 2,6-dibromo-N-(3-phenylphenyl)pyridin-4-amine
• CAS: 920752-36-9
• 化学式: C₁₇H₁₂Br₂N₂
• 分子量: 404.104
• InChiKey: VHLVUNGUYQJICX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二溴-4-硝基吡啶氮氧化物 在 正丁基锂 、 三溴化磷 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 20.0h， 生成 N-([1,1'-Biphenyl]-3-yl)-2,6-dibromopyridin-4-amine
  参考文献：
  名称：

  Regioselective synthesis of 2,4,6-triaminopyridines

  摘要：

  A regioselective synthesis of 2,4,6-trisubstituted pyridine is described starting from 2,6-dibromo-4-nitropyridine. All three different regioisomers of the 2,4,6-triamino substituted pyridine have been synthesized in four to five steps. The method described is a general route to unsymmetrical 2,4,6-trisubstituted amino pyridines. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.159

文献信息

• Regioselective synthesis of 2,4,6-triaminopyridines
  作者：Rupa Shetty、Duyan Nguyen、Dietmar Flubacher、Franziska Ruggle、Andreas Schumacher、Martha Kelly、Enrique Michelotti

  DOI：10.1016/j.tetlet.2006.10.159

  日期：2007.1

  A regioselective synthesis of 2,4,6-trisubstituted pyridine is described starting from 2,6-dibromo-4-nitropyridine. All three different regioisomers of the 2,4,6-triamino substituted pyridine have been synthesized in four to five steps. The method described is a general route to unsymmetrical 2,4,6-trisubstituted amino pyridines. (c) 2006 Elsevier Ltd. All rights reserved.