| 1251916-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1251916-20-7
• 化学式: C₂₉H₂₉NO₂
• 分子量: 423.555
• InChiKey: HSTYLSPXKWIIFC-BFNWXZRRSA-N

反应信息

• 作为产物：
  描述：

  在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以52%的产率得到
  参考文献：
  名称：

  Traceless solid-phase synthesis of N-substituted 3,5-bis(substituted-idene)piperidin-4-one derivatives

  摘要：

  A series of N-substituted 3,5-bis(substituted-idene)piperidin-4-ones have been prepared using solid-phase organic synthesis. The synthesis starts with a Michael addition with piperidin-4-one serving as the donor and REM resin as the acceptor. Various aldehydes were then utilized through a Knoevenagel condensation to afford the 3,5-bis(substituted-idene)piperidin-4-ones on the solid support. The final products were removed from the support and a second diversity position was introduced through a Hofmann elimination using different alkyl bromides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.072