AL-05712 | 131760-66-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AL-05712
• 英文别名: N,N'-dimethyl-N,N'-bishydrazine；N,N'-dimethyl-N,N'-bis[acetylthio(acetyl)]hydrazine；S-[2-[[(2-acetylsulfanylacetyl)-methylamino]-methylamino]-2-oxoethyl] ethanethioate
• CAS: 131760-66-2
• 化学式: C₁₀H₁₆N₂O₄S₂
• 分子量: 292.38
• InChiKey: XGBGHXUHZUXRCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  AL-05712 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 80.0h， 以78%的产率得到N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
  参考文献：
  名称：

  A reagent for reduction of disulfide bonds in proteins that reduces disulfide bonds faster than does dithiothreitol

  摘要：

  We have synthesized a new reagent--N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine (DMH)-for the reduction of disulfide bonds in proteins. DMH reduces disulfid bonds 7 times faster than does dithiothreitol (DTT) in water at pH 7. DMH reduces mixed disulfides of cysteine proteases (papain and ficin) especially rapdily (30 times faster than DTT). DMH (epsilon-degrees = -0.300 V) reduces noncyclic disulfides completely, although it is less strongly reducing than DTT (epsilon-degrees = -0.356 V).

  DOI：

  10.1021/jo00007a018
• 作为产物：
  描述：

  N,N'-dimethyl-N,N'-bis(chloroacetyl)hydrazine 、 硫代乙酸 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以94%的产率得到AL-05712
  参考文献：
  名称：

  A reagent for reduction of disulfide bonds in proteins that reduces disulfide bonds faster than does dithiothreitol

  摘要：

  We have synthesized a new reagent--N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine (DMH)-for the reduction of disulfide bonds in proteins. DMH reduces disulfid bonds 7 times faster than does dithiothreitol (DTT) in water at pH 7. DMH reduces mixed disulfides of cysteine proteases (papain and ficin) especially rapdily (30 times faster than DTT). DMH (epsilon-degrees = -0.300 V) reduces noncyclic disulfides completely, although it is less strongly reducing than DTT (epsilon-degrees = -0.356 V).

  DOI：

  10.1021/jo00007a018

文献信息

• SINGH, RAJEEVA;WHITESIDES, GEORGE M., J. ORG. CHEM., 56,(1991) N, C. 2332-2337
  作者：SINGH, RAJEEVA、WHITESIDES, GEORGE M.

  DOI：——

  日期：——
• A reagent for reduction of disulfide bonds in proteins that reduces disulfide bonds faster than does dithiothreitol
  作者：Rajeeva Singh、George M. Whitesides

  DOI：10.1021/jo00007a018

  日期：1991.3

  We have synthesized a new reagent--N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine (DMH)-for the reduction of disulfide bonds in proteins. DMH reduces disulfid bonds 7 times faster than does dithiothreitol (DTT) in water at pH 7. DMH reduces mixed disulfides of cysteine proteases (papain and ficin) especially rapdily (30 times faster than DTT). DMH (epsilon-degrees = -0.300 V) reduces noncyclic disulfides completely, although it is less strongly reducing than DTT (epsilon-degrees = -0.356 V).