9-fluoro-7-(5-fluoro-4-(pyrrolidin-1-yl)pyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline | 1464115-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 9-fluoro-7-(5-fluoro-4-(pyrrolidin-1-yl)pyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline
• 英文别名: 9-Fluoro-7-(5-fluoro-4-pyrrolidin-1-ylpyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline
• CAS: 1464115-36-3
• 化学式: C₂₀H₁₉F₂N₅
• 分子量: 367.401
• InChiKey: WNGPZOMYGDQNMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] ALDOSTERONE SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS D'ALDOSTÉRONE SYNTHASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013151876A1

  公开（公告）日：2013-10-10

  This invention relates to tricyclic triazole compounds or their pharmaceutically acceptable salts. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the above-cited compounds or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

  本发明涉及三环三唑化合物或其药用盐。这些创新化合物选择性抑制醛固酮合成酶。本发明还提供了包括上述化合物或其盐的药物组合物，以及可能用于通过抑制醛固酮合成酶治疗、改善或预防可通过抑制醛固酮合成酶治疗的疾病的方法。
• ALDOSTERONE SYNTHASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150306091A1

  公开（公告）日：2015-10-29

  This invention relates to tricyclic triazole compounds or their pharmaceutically acceptable salts. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the above-cited compounds or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

  本发明涉及三环三唑化合物或其药学上可接受的盐。这些创新化合物能够选择性地抑制醛固酮合成酶。本发明还提供了包含上述化合物或其盐的制药组合物，以及用于治疗、改善或预防可以通过抑制醛固酮合成酶来治疗的疾病的方法。
• US9278093B2
  申请人：——

  公开号：US9278093B2

  公开（公告）日：2016-03-08