(2S)-2-methyl-3-(4-phenylphenyl)propan-1-ol | 198641-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-methyl-3-(4-phenylphenyl)propan-1-ol
• CAS: 198641-82-6
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: ICIPORXKZXHVHV-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2S)-2-methyl-3-(4-phenylphenyl)propan-1-ol 在 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

  摘要：

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10067-1
• 作为产物：
  描述：

  4-甲基联苯 在 N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 正丁基锂 、 苄硫醇 、 lithium hexamethyldisilazane 作用下， 以 四氯化碳 为溶剂， 生成 (2S)-2-methyl-3-(4-phenylphenyl)propan-1-ol
  参考文献：
  名称：

  Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

  摘要：

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10067-1

文献信息

• TUBULYSINE DERIVATIVES
  申请人：Richter Wolfgang

  公开号：US20120129779A1

  公开（公告）日：2012-05-24

  The present invention relates to novel cytotoxic molecules and their use for the treatment of cancer and other diseases.
• US8980833B2
  申请人：——

  公开号：US8980833B2

  公开（公告）日：2015-03-17
• Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin
  作者：Richard Göschke、Nissim Claude Cohen、Jeanette M. Wood、Jürgen Maibaum

  DOI：10.1016/s0960-894x(97)10067-1

  日期：1997.11

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.