4-(4-Hydroxy-3-iod-phenoxy)-3,5-diiod-benzylalkohol | 842-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Hydroxy-3-iod-phenoxy)-3,5-diiod-benzylalkohol
• 英文别名: 4-(4-hydroxymethyl-2,6-diiodophenoxy)-2-iodo-phenol；4-[4-(Hydroxymethyl)-2,6-diiodophenoxy]-2-iodophenol
• CAS: 842-33-1
• 化学式: C₁₃H₉I₃O₃
• 分子量: 593.926
• InChiKey: SDQXRFBYSPDKOZ-UHFFFAOYSA-N

物化性质

• 沸点：
  492.1±45.0 °C(Predicted)
• 密度：
  2.490±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-羟基-3-碘苯氧基)-3,5-二碘苯甲酸 在 diborane(6) 作用下， 以 四氢呋喃 为溶剂， 生成 4-(4-Hydroxy-3-iod-phenoxy)-3,5-diiod-benzylalkohol
  参考文献：
  名称：

  降胆固醇药。胸烷醇。

  摘要：

  DOI：

  10.1021/jm00328a013

文献信息

• Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
  申请人：——

  公开号：US20020123521A1

  公开（公告）日：2002-09-05

  The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR-&agr; or TR-&bgr; with an equilibrium dissociation constant, K d , of at least 10 −5 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.

  本发明涉及一种治疗皮肤真皮萎缩的方法。本发明的方法包括在患有皮肤真皮萎缩的哺乳动物的皮肤上施用一种组合物，该组合物包含至少一种甲状腺激素化合物或甲状腺激素样化合物以及适合局部施用的药理学上可接受的基质，其中甲状腺激素化合物或甲状腺激素样化合物与TR-&agr;或TR-&bgr;结合，其平衡解离常数K d 至少为 10 -5 M.本发明还涉及一种制造品，包括包装材料和包含在包装材料中的药剂，其中药剂对治疗皮肤真皮萎缩具有治疗效果。
• NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS
  申请人：KARO BIO AB

  公开号：EP1328265A2

  公开（公告）日：2003-07-23
• US6380255B1
  申请人：——

  公开号：US6380255B1

  公开（公告）日：2002-04-30
• [EN] NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS<br/>[FR] NOUVELLES UTILISATIONS D'HORMONES DE LA THYROIDE OU DE COMPOSES AGONISTES SEMBLABLES A L'HORMONE DE LA THYROIDE
  申请人：KAROBIO AB

  公开号：WO2002005834A2

  公开（公告）日：2002-01-24

  The present invention is directed to the sue of at least one thyroid hormone compound or thyroid hormone-like agonist compound in the preparation of a topical medicament for the treatment of a dermatological condition affecting the dermis. The thyroid hormone compound or the thyroid hormone-like agonist compound binds to TR-α or TR-β with an equilibrium dissociation constant, Kd, of less than 5 x 10-6 M. The invention is also directed to a composition for treating a dermatological conditions affecting the dermis and to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating such a condition. Use of at least one thyroid hormone or thyroid hormone-like agonist compound in the preparation of a topical medicament for the pre-treatment of skin in dermatological surgery is also provided.