2-O-[2-(5-bromo-1,3-thiazol-2-yl)-2-oxoethyl] 1-O-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate | 1334313-99-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-O-[2-(5-bromo-1,3-thiazol-2-yl)-2-oxoethyl] 1-O-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate
• CAS: 1334313-99-3
• 化学式: C₁₅H₁₉BrN₂O₅S
• 分子量: 419.296
• InChiKey: WONRVAAFNXMLIB-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2545060B1

  公开（公告）日：2015-11-25
• ANTIVIRAL COMPOUNDS OF THREE LINKED ARYL MOIETIES TO TREAT DISEASES SUCH AS HEPATITIS C
  申请人：Zeng Qingbei

  公开号：US20120258078A1

  公开（公告）日：2012-10-11

  The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. in one aspect, the present invention provides Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein: Non-limiting examples of the Compounds of Formula (II) include compound 56
• US8980920B2
  申请人：——

  公开号：US8980920B2

  公开（公告）日：2015-03-17
• [EN] FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES<br/>[FR] COMPOSÉS TRICYCLIQUES FUSIONNÉS DE SILYLE ET LEURS MÉTHODES D'UTILISATION DANS LE CADRE DU TRAITEMENT DE MALADIES VIRALES
  申请人：SCHERING CORP

  公开号：WO2011112429A1

  公开（公告）日：2011-09-15

  The present invention relates to novel Fused Tricyclic SiIyI Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, M1, X1 and X2 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Silyl Compound, and methods of using the Fused Tricyclic Silyl Compounds for treating or preventing HCV infection in a patient.