4-氨基-6-氯-2-二乙基氨基嘧啶 | 3289-38-1

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-氨基-6-氯-2-二乙基氨基嘧啶
• 英文名称: 4-amino-6-chloro-2-diethylaminopyrimidine
• 英文别名: 6-chloro-N²,N²-diethyl-pyrimidine-2,4-diamine；4-Amino-6-chlor-2-diaethylamino-pyrimidin；6-chloro-N2,N2-diethylpyrimidine-2,4-diamine；6-chloro-2-N,2-N-diethylpyrimidine-2,4-diamine
• CAS: 3289-38-1
• 化学式: C₈H₁₃ClN₄
• mdl: MFCD09743981
• 分子量: 200.671
• InChiKey: XZIIFPSPUDAGJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 4-氨基-6-氯-2-二乙基氨基嘧啶 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85%的产率得到
  参考文献：
  名称：

  A practical strategy for the synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines

  摘要：

  Starting from commercially available 4-amino-2,6-dichloropyrimidine, a practical four steps synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines was developed. This strategy could introduce a diverse set of secondary amines and arylamines to displace the 2- and 4-chloro groups. The products of this route are otherwise difficult to access. In addition, 6-amino arylation was carried out to demonstrate the reactivity and utility of 2-dialkylamino-4-arylamino-6-aminopyrimidines as building blocks for assembling interesting aminopyrimidine molecules. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.154
• 作为产物：
  描述：

  4-氨基-2,6-二氯嘧啶 、 二乙胺 在 N,N-二异丙基乙胺 作用下， 以 异丙醇 为溶剂， 以90%的产率得到4-氨基-6-氯-2-二乙基氨基嘧啶
  参考文献：
  名称：

  A practical strategy for the synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines

  摘要：

  Starting from commercially available 4-amino-2,6-dichloropyrimidine, a practical four steps synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines was developed. This strategy could introduce a diverse set of secondary amines and arylamines to displace the 2- and 4-chloro groups. The products of this route are otherwise difficult to access. In addition, 6-amino arylation was carried out to demonstrate the reactivity and utility of 2-dialkylamino-4-arylamino-6-aminopyrimidines as building blocks for assembling interesting aminopyrimidine molecules. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.154

文献信息

• Yellow Azo Dyes for Ink Jet Printing
  申请人：Wright Gavin

  公开号：US20100068472A1

  公开（公告）日：2010-03-18

  Monomers and dimers of mono-azo compounds of formula wherein: D is an optionally substituted aryl or an optionally substituted heteroaryl group; R 1 and R 2 are each independently optionally substituted alkyl: halo: amino: —NR 4 R 5 ; wherein R 4 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl; and R 5 is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl or R 4 together with R 5 and the nitrogen to which they are attached forms an optionally substituted 5 or 6 membered ring: —OR 6 ; wherein R 6 is H or optionally substituted alkyl: or —SR 7 ; wherein R 7 is optionally substituted alkyl; R 3 is amino: halo; —NR 4 R 5 ; wherein R 4 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl; and R 5 is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl or R 4 together with R 5 and the nitrogen to which they are attached forms an optionally substituted 5 or 6 membered ring: hydroxy: —OR 6 ; wherein R 6 is H or optionally substituted alkyl: or —SR 7 ; wherein R 7 is optionally substituted alkyl. Also compositions, inks and ink-jet cartridges containing these compounds and ink-jet printing processes using these compounds.

  单偶氮化合物的单体和二聚体，化学式如下：其中：D是可选择取代的芳基或可选择取代的杂环基；R1和R2各自独立地是可选择取代的烷基、卤素、氨基、-NR4R5；其中R4是H、可选择取代的烷基、可选择取代的烷氧基、可选择取代的酰基、可选择取代的芳基、可选择取代的杂环基；R5是可选择取代的烷基、可选择取代的烷氧基、可选择取代的酰基、可选择取代的芳基、可选择取代的杂环基或者R4和R5以及它们所连接的氮原子形成可选择取代的5或6元环；-OR6；其中R6是H或可选择取代的烷基；或-SR7；其中R7是可选择取代的烷基；R3是氨基、卤素、-NR4R5；其中R4是H、可选择取代的烷基、可选择取代的烷氧基、可选择取代的酰基、可选择取代的芳基、可选择取代的杂环基；R5是可选择取代的烷基、可选择取代的烷氧基、可选择取代的酰基、可选择取代的芳基、可选择取代的杂环基或者R4和R5以及它们所连接的氮原子形成可选择取代的5或6元环；羟基；-OR6；其中R6是H或可选择取代的烷基；或-SR7；其中R7是可选择取代的烷基。此外，还包括含有这些化合物的组合物、油墨和喷墨墨盒以及使用这些化合物的喷墨打印工艺。
• Guillier, Fabrice; Roussel, Patrick; Moser, Heinz, Chemistry - A European Journal, 1999, vol. 5, # 12, p. 3450 - 3458
  作者：Guillier, Fabrice、Roussel, Patrick、Moser, Heinz、Kane, Peter、Bradley, Mark

  DOI：——

  日期：——
• Hurst, Derek, T.; Johnson, Matthew, Heterocycles, 1985, vol. 23, # 3, p. 611 - 616
  作者：Hurst, Derek, T.、Johnson, Matthew

  DOI：——

  日期：——
• HURST, D. T.;JOHNSON, M., HETEROCYCLES, 1985, 23, N 3, 611-616
  作者：HURST, D. T.、JOHNSON, M.

  DOI：——

  日期：——
• Ink-Jet Printing Using Disazo Dyes
  申请人：James Rachel Anne

  公开号：US20090017278A1

  公开（公告）日：2009-01-15

  Compounds of Formula (1) and dimers thereof: wherein: A and B independently are optionally substituted aryl or optionally substituted heteroaryl groups; R 1 and R 2 are each independently optionally substituted alkyl: halo: amino: —NR 4 R 5 ; wherein R 4 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl; and R 5 is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl or R 4 together with R 5 and the nitrogen to which they are attached forms an optionally substituted 5 or 6 membered ring: —OR 6 ; wherein R 6 is H or optionally substituted alkyl: or —SR 7 ; wherein R 7 is optionally substituted alkyl; R 3 is optionally substituted alkyl: halo: amino: —NR 4 R 5 ; wherein R 4 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl; and R 5 is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted acyl, optionally substituted aryl, optionally substituted heterocyclyl or R 4 together with R 5 and the nitrogen to which they are attached forms an optionally substituted 5 or 6 membered ring: —OR 6 ; wherein R 6 is H or optionally substituted alkyl: or —SR 7 ; wherein R 7 is optionally substituted alkyl; also ink-jet inks and processes and printed materials.