(Z)-4-(oct-1-en-1-yl)benzylalcohol | 1338833-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-(oct-1-en-1-yl)benzylalcohol
• 英文别名: [4-[(Z)-oct-1-enyl]phenyl]methanol
• CAS: 1338833-96-7
• 化学式: C₁₅H₂₂O
• 分子量: 218.339
• InChiKey: XJPWHMBYMMAGPD-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正庚基三苯基溴化磷 、 对羟基甲基苯甲醛 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 21.0h， 生成 (Z)-4-(oct-1-en-1-yl)benzylalcohol 、 (E)-4-(oct-1-en-1-yl)benzylalcohol
  参考文献：
  名称：

  A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry

  摘要：

  A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule. (C) 2011 Elsevier Ltd. All rights reserved,

  DOI：

  10.1016/j.tetlet.2011.08.100

文献信息

• A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry
  作者：Janice Calzavara、James McNulty

  DOI：10.1016/j.tetlet.2011.08.100

  日期：2011.10

  A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule. (C) 2011 Elsevier Ltd. All rights reserved,