2-chloro-N-(2,4,6-trimethyltetrahydro-2H-pyran-4-yl)acetamide | 851389-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-chloro-N-(2,4,6-trimethyltetrahydro-2H-pyran-4-yl)acetamide
• 英文别名: 2-Chloro-N-(tetrahydro-2,4,6-trimethyl-2H-pyran-4-yl)acetamide；2-chloro-N-(2,4,6-trimethyloxan-4-yl)acetamide
• CAS: 851389-43-0
• 化学式: C₁₀H₁₈ClNO₂
• 分子量: 219.711
• InChiKey: XZHODVBRILUJCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-N-(2,4,6-trimethyltetrahydro-2H-pyran-4-yl)acetamide 在 硫脲 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 2.0h， 生成 (2,4,6-trimethyltetrahydro-2H-pyran-4-yl)amine
  参考文献：
  名称：

  [EN] 2-CYANOPYRROLIDINECARBOXAMIDES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
  [FR] COMPOSE 2-CYANOPYRROLIDINECARBOXAMIDE

  摘要：

  公开号：

  WO2005042533A3

文献信息

• 2-Cyanopyrrolidinecarboxamide compound
  申请人：Shima Ichiro

  公开号：US20050137224A1

  公开（公告）日：2005-06-23

  A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X 1 and X 2 each is independently lower alkylene; X 3 is ═CH 2 , ═CHF or ═CF 2 ; R 1 is substituent, R 2 and R 3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.]having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.

  化合物的公式（I）或其药学上可接受的盐：[其中X1和X2各自独立地是较低的烷基；X3为═CH2，═CHF或═CF2；R1为取代基，R2和R3各自独立地为H或较低的烷基；n为0、1、2、3或4]具有抑制DPP-IV活性的活性。因此，它们在治疗由DPP-IV介导的疾病，如NIDDM中是有用的。
• 2-cyanopyrrolidinecarboxamide compound
  申请人：Astellas Pharma Inc.

  公开号：US07186731B2

  公开（公告）日：2007-03-06

  A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ═CH2, ═CHF or ═CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.

  化合物的公式（I）或其药学上可接受的盐：[其中X1和X2各自独立地为低烷基；X3为═CH2，═CHF或═CF2；R1为取代基，R2和R3各自独立地为H或低烷基；n为0、1、2、3或4]具有抑制DPP-IV活性的活性。因此，它们在治疗由DPP-IV介导的疾病，如NIDDM方面是有用的。
• 2-CYANOPYRROLIDINECARBOXAMIDES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
  申请人：Astellas Pharma Inc.

  公开号：EP1737863A2

  公开（公告）日：2007-01-03
• US7186731B2
  申请人：——

  公开号：US7186731B2

  公开（公告）日：2007-03-06
• [EN] 2-CYANOPYRROLIDINECARBOXAMIDE COMPOUND<br/>[FR] COMPOSE 2-CYANOPYRROLIDINECARBOXAMIDE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2005042533A2

  公开（公告）日：2005-05-12

  A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is =CH2, =CHF or =CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.