(+/-)-N-cyclobutyl-2-(2-(2-methoxy-4-morpholinophenylamino)-5-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide | 1312162-60-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (+/-)-N-cyclobutyl-2-(2-(2-methoxy-4-morpholinophenylamino)-5-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
• 英文别名: N-cyclobutyl-2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide
• CAS: 1312162-60-9
• 化学式: C₂₈H₃₅N₇O₄S
• 分子量: 565.696
• InChiKey: HDMVWFNQIJVQKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• Fully Backbone Degradable and Functionalizable Polymers Derived from the Ring-Opening Metathesis Polymerization (ROMP)
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20130281644A1

  公开（公告）日：2013-10-24

  Functionalized degradable ROMP (ring-opening metathesis) polymers and methods, starting monomers and synthetic monomeric and polymeric intermediates for preparation of such functionalized polymers. More specifically, monomers having a bicyclic oxazinone structure, a bicyclic urea, or a heteronorbornene core structure, among others, have been found to be substrates for ROMP polymerization. ROMP polymers prepared from these monomers have been found to be both acid and base labile. Additionally, the monomers can be chemically modified at a site distal to the polymerizable moieties and bridgehead carbons. The properties of the resulting polymers and copolymers can be tailored without destabiling the monomer. Polymers and copolymers of the invention are degradable but have a glass temperature of 100° C. or more.

  可降解的功能化ROMP（环开放重聚合）聚合物及其制备方法、起始单体和合成单体和聚合中间体，用于制备这种功能化聚合物。更具体地说，已发现具有双环氧氮杂环结构、双环脲或杂环辛烷烯核心结构等单体是ROMP聚合的底物。从这些单体制备的ROMP聚合物已发现既具有酸性又具有碱性的不稳定性。此外，这些单体可以在可聚合基团和桥头碳远离的位置进行化学修饰。所得聚合物和共聚物的性质可以定制而不破坏单体。发明的聚合物和共聚物可降解，但具有100℃或更高的玻璃转移温度。
• US9206271B2
  申请人：——

  公开号：US9206271B2

  公开（公告）日：2015-12-08
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30