2-n-butylbutanedioic acid 4-tert-butyl monoester | 946831-42-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-n-butylbutanedioic acid 4-tert-butyl monoester
• 英文别名: 2-[2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]hexanoic acid
• CAS: 946831-42-1
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: PRKYQKFRMIJBQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-n-butylbutanedioic acid 4-tert-butyl monoester 在 (S)-(-)- α-甲基苄胺 、 盐酸 作用下， 以 水 为溶剂， 生成 (R)-(+)-2-丁基丁二酸 4-叔丁酯
  参考文献：
  名称：

  Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

  摘要：

  A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound la with unsubstituted benzimidazole ring exhibited potent antibacterial activities. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.05.009
• 作为产物：
  描述：

  4-(tert-butyl) 1-methyl 2-butylsuccinate 在 lithium hydroxide 、 水 作用下， 以 甲醇 为溶剂， 生成 2-n-butylbutanedioic acid 4-tert-butyl monoester
  参考文献：
  名称：

  Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

  摘要：

  A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound la with unsubstituted benzimidazole ring exhibited potent antibacterial activities. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.05.009

文献信息

• Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof
  申请人：Kang Jae-Hoon

  公开号：US20080234333A1

  公开（公告）日：2008-09-25

  The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient.

  本发明涉及具有强效抗菌活性的新型抗菌化合物，作为肽变形酶抑制剂。本发明还涉及其药用盐、其制备方法以及含有其作为活性成分的药物组合物。
• [EN] NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS<br/>[FR] NOUVEAUX COMPOSÉS, LEURS COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES D'UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：EUROSCREEN SA

  公开号：WO2011151434A1

  公开（公告）日：2011-12-08

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

  本发明涉及公式（I）的新化合物及其在治疗代谢性疾病中的应用。
• COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
  申请人：Hoveyda Hamid

  公开号：US20110230477A1

  公开（公告）日：2011-09-22

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

  本发明涉及式（I）的新化合物及其在治疗代谢性疾病方面的应用。
• Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
  申请人：Euroscreen S.A.

  公开号：EP2364297A1

  公开（公告）日：2011-09-14
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS<br/>[FR] COMPOSÉS, COMPOSITION PHARMACEUTIQUE ET MÉTHODES POUR APPLICATION AU TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：EUROSCREEN SA

  公开号：WO2010066682A1

  公开（公告）日：2010-06-17

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.